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Gouëffic, Y; Brodmann, M; Deloose, K; Dubosq-Lebaz, M; Nordanstig, J.
Drug-eluting devices for lower limb peripheral arterial disease.
EuroIntervention. 2024; 20(18):e1136-e1153
Doi: 10.4244/EIJ-D-23-01080
[OPEN ACCESS]
Web of Science
PubMed
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- Co-authors Med Uni Graz
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Brodmann Marianne
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- Abstract:
- Peripheral arterial disease is the third leading cause of cardiovascular morbidity after coronary artery disease and stroke. Lower limb peripheral arterial disease commonly involves infrainguinal arteries, may impair walking ability (intermittent claudication) and may confer a significant risk of limb loss (chronic limb-threatening ischaemia), depending on the severity of ischaemia. Endovascular treatment has become the mainstay revascularisation option in both the femoropopliteal and the below-the-knee arterial segments. After crossing and preparing the lesion, treatment results in these arterial segments can be enhanced by using drug-coated devices (drug-eluting stents and drug-coated balloons) that mitigate the occurrence of restenosis. As for other medical devices, the use of drug-eluting devices is based on their demonstrated safety and efficacy profiles when applied in the distinct segments of the lower limb vasculature. In this state-of-the-art narrative review we provide an overview of the safety and efficacy of drug-coated devices when used in the femoropopliteal and below-the-knee arterial segments.
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Humans - administration & dosage
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Peripheral Arterial Disease - therapy, physiopathology
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Drug-Eluting Stents - administration & dosage
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Lower Extremity - blood supply
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Endovascular Procedures - instrumentation, methods
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Popliteal Artery - administration & dosage
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Treatment Outcome - administration & dosage
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Femoral Artery - administration & dosage
- Find related publications in this database (Keywords)
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drug-coated balloons
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drug-eluting stents
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-limus
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paclitaxel
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safety