Medizinische Universität Graz - Research portal
Selected Publication:
SHR Neuro Cancer Cardio Lipid Metab Microb
Leonhardi, J; Sabanov, A; Höhn, AK; Sucher, R; Seehofer, D; Mehdorn, M; Schnarkowski, B; Ebel, S; Denecke, T; Meyer, HJ.
CT Texture Analysis of Perihilar Cholangiocarcinoma-Associations With Tumor Grading, Tumor Markers and Clinical Outcome.
Cancer Rep (Hoboken). 2024; 7(9): e2132
Doi: 10.1002/cnr2.2132
[OPEN ACCESS]
Web of Science
PubMed
FullText
FullText_MUG
- Co-authors Med Uni Graz
- Sucher Robert
- Altmetrics:
- Dimensions Citations:
- Plum Analytics:
- Scite (citation analytics):
- Abstract:
- BACKGROUND: Texture analysis derived from computed tomography (CT) may provide clinically relevant imaging biomarkers associated with tumor histopathology. Perihilar cholangiocarcinoma is a malignant disease with an overall poor prognosis. AIMS: The present study sought to elucidate possible associations between texture features derived from CT images with grading, tumor markers, and survival in extrahepatic, perihilar cholangiocarcinomas tumors. METHODS: This retrospective study included 22 patients (10 females, 45%) with a mean age of 71.8 ± 8.7 years. Texture analysis was performed using the free available Mazda software. All tumors were histopathologically confirmed. Survival and clinical parameters were used as primary study outcomes. RESULTS: In discrimination analysis, "S(1,1)SumVarnc" was statistically significantly different between patients with long-term survival and nonlong-term survival (mean 275.8 ± 32.6 vs. 239.7 ± 26.0, p = 0.01). The first-order parameter "skewness" was associated with the tumor marker "carcinoembryonic antigen" (CEA) (r = -0.7, p = 0.01). A statistically significant correlation of the texture parameter "S(5,0)SumVarnc" with tumor grading was identified (r = -0.6, p < 0.01). Several other texture features correlated with tumor markers CA-19-9 and AFP, as well as with T and N stage of tumors. CONCLUSION: Several texture features derived from CT images were associated with tumor characteristics and survival in patients with perihilar cholangiocarcinomas. CT texture features could be used as valuable novel imaging markers in clinical routine.
- Find related publications in this database (using NLM MeSH Indexing)
- Humans - administration & dosage
- Female - administration & dosage
- Male - administration & dosage
- Aged - administration & dosage
- Bile Duct Neoplasms - pathology, diagnostic imaging, mortality
- Retrospective Studies - administration & dosage
- Klatskin Tumor - pathology, diagnostic imaging, mortality
- Biomarkers, Tumor - analysis
- Middle Aged - administration & dosage
- Tomography, X-Ray Computed - administration & dosage
- Neoplasm Grading - administration & dosage
- Aged, 80 and over - administration & dosage
- Prognosis - administration & dosage
- Find related publications in this database (Keywords)
- computed tomography
- extrahepatic cholangiocarcinoma
- Klatskin tumor
- texture analysis