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Selected Publication:
SHR Neuro Cancer Cardio Lipid Metab Microb
Englisch, C; Moik, F; Steiner, D; Starzer, AM; Berghoff, AS; Preusser, M; Pabinger, I; Ay, C.
Bleeding events in patients with cancer: incidence, risk factors, and impact on prognosis in a prospective cohort study.
Blood. 2024; 144(22):2349-2359
Doi: 10.1182/blood.2024025362
Web of Science
PubMed
FullText
FullText_MUG
- Co-authors Med Uni Graz
- Moik Florian
- Steiner Daniel
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- Abstract:
- Hemostatic imbalances are frequent in patients with cancer. Although cancer-associated thrombotic complications have been well characterized, data on bleeding events in patients with cancer are sparse. Therefore, we aimed to investigate the incidence, risk factors, and impact on prognosis of bleeding events in patients with cancer initiating systemic anticancer therapies in a prospective cohort study, the Vienna Cancer, Thrombosis, and Bleeding Study. The primary study outcome was defined as clinically relevant bleeding (CRB), comprising major bleeding (MB) and clinically relevant nonmajor bleeding. In total, 791 patients (48% female), with median age of 63 years (interquartile range [IQR], 54-70), with various cancer types, 65.5% stage IV, were included. Over a median follow-up of 19 months (IQR, 8.7-24.0), we observed 194 CRB events in 139 (17.6%) patients, of which 42 (30.0%) were tumor related, 64 (46.0%) gastrointestinal, and 7 (5.0%) intracerebral. The 12-month cumulative incidence of first CRB and MB was 16.6% (95% confidence interval [CI], 13.7-19.6) and 9.1% (95% CI, 6.8-11.3), respectively, in the whole cohort, and 14.4% (95% CI, 11.2-17.5) and 7.0% (95% CI, 4.7-9.2), respectively, in those without anticoagulation. Patients with head and neck cancer had the highest risk of CRB. Lower baseline hemoglobin and albumin were associated with bleeding in patients without anticoagulation. Seven (5.0%) bleeding events were fatal, of which 6 occurred in patients without anticoagulation. Patients with CRB were at an increased risk of all-cause mortality (multivariable transition hazard ratio, 5.80; 95% CI, 4.53-7.43). In patients with cancer, bleeding events represent a frequent complication and are associated with increased mortality.
- Find related publications in this database (using NLM MeSH Indexing)
- Humans - administration & dosage
- Female - administration & dosage
- Middle Aged - administration & dosage
- Male - administration & dosage
- Neoplasms - complications, epidemiology
- Aged - administration & dosage
- Prospective Studies - administration & dosage
- Incidence - administration & dosage
- Risk Factors - administration & dosage
- Hemorrhage - epidemiology, etiology
- Prognosis - administration & dosage
- Follow-Up Studies - administration & dosage