Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Divilly, P; Martine-Edith, G; Zaremba, N; Søholm, U; Mahmoudi, Z; Cigler, M; Ali, N; Abbink, EJ; Brøsen, J; de, Galan, B; Pedersen-Bjergaard, U; Vaag, AA; McCrimmon, RJ; Renard, E; Heller, S; Evans, M; Mader, JK; Amiel, SA; Pouwer, F; Choudhary, P, , Hypo-RESOLVE, Consortium.
Relationship Between Sensor-Detected Hypoglycemia and Patient-Reported Hypoglycemia in People With Type 1 and Insulin-Treated Type 2 Diabetes: The Hypo-METRICS Study.
Diabetes Care. 2024; 47(10):1769-1777
Doi: 10.2337/dc23-2332
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- Co-Autor*innen der Med Uni Graz
- Cigler Monika
- Mader Julia
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- Abstract:
- OBJECTIVE: Use of continuous glucose monitoring (CGM) has led to greater detection of hypoglycemia; the clinical significance of this is not fully understood. The Hypoglycaemia-Measurement, Thresholds and Impacts (Hypo-METRICS) study was designed to investigate the rates and duration of sensor-detected hypoglycemia (SDH) and their relationship with person-reported hypoglycemia (PRH) in people living with type 1 diabetes (T1D) and insulin-treated type 2 diabetes (T2D) with prior experience of hypoglycemia. RESEARCH DESIGN AND METHODS: We recruited 276 participants with T1D and 321 with T2D who wore a blinded CGM and recorded PRH in the Hypo-METRICS app over 10 weeks. Rates of SDH <70 mg/dL, SDH <54 mg/dL, and PRH were expressed as median episodes per week. Episodes of SDH were matched to episodes of PRH that occurred within 1 h. RESULTS: Median [interquartile range] rates of hypoglycemia were significantly higher in T1D versus T2D; for SDH <70 mg/dL (6.5 [3.8-10.4] vs. 2.1 [0.8-4.0]), SDH <54 mg/dL (1.2 [0.4-2.5] vs. 0.2 [0.0-0.5]), and PRH (3.9 [2.4-5.9] vs. 1.1 [0.5-2.0]). Overall, 65% of SDH <70 mg/dL was not associated with PRH, and 43% of PRH had no associated SDH. The median proportion of SDH associated with PRH in T1D was higher for SDH <70 mg/dL (40% vs. 22%) and SDH <54 mg/dL (47% vs. 25%) than in T2D. CONCLUSIONS: The novel findings are that at least half of CGM hypoglycemia is asymptomatic, even below 54 mg/dL, and many reported symptomatic hypoglycemia episodes happen above 70 mg/dL. In the clinical and research setting, these episodes cannot be used interchangeably, and both need to be recorded and addressed.
- Find related publications in this database (using NLM MeSH Indexing)
- Humans - administration & dosage
- Diabetes Mellitus, Type 2 - drug therapy, blood, complications
- Hypoglycemia - blood, chemically induced, diagnosis
- Diabetes Mellitus, Type 1 - drug therapy, blood, complications
- Female - administration & dosage
- Male - administration & dosage
- Middle Aged - administration & dosage
- Blood Glucose Self-Monitoring - administration & dosage
- Insulin - therapeutic use, adverse effects
- Adult - administration & dosage
- Blood Glucose - analysis, metabolism, drug effects
- Aged - administration & dosage
- Hypoglycemic Agents - therapeutic use, adverse effects