Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Skerjanz, J; Bauernhofer, L; Lenk, K; Emmerstorfer-Augustin, A; Leitinger, G; Reichmann, F; Stockner, T; Groschner, K; Tiapko, O.
TRPC1: The housekeeper of the hippocampus
CELL CALCIUM. 2024; 123: 102933
Doi: 10.1016/j.ceca.2024.102933
Web of Science
PubMed
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FullText_MUG
- Führende Autor*innen der Med Uni Graz
- Skerjanz Julia
- Tiapko Oleksandra
- Co-Autor*innen der Med Uni Graz
- Groschner Klaus
- Leitinger Gerd
- Reichmann Florian
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- Abstract:
- The non-selective cation channel TRPC1 is highly expressed in the brain. Recent research shows that neuronal TRPC1 forms heteromeric complexes with TRPC4 and TRPC5, with a small portion existing as homotetramers, primarily in the ER. Given that most studies have focused on the role of heteromeric TRPC1/4/5 complexes, it is crucial to investigate the specific role of homomeric TRPC1 in maintaining brain homeostasis. This review highlights recent findings on TRPC1 in the brain, with a focus on the hippocampus, and compiles the latest data on modulators and their binding sites within the TRPC1/4/5 subfamily to stimulate new research on more selective TRPC1 ligands.
- Find related publications in this database (Keywords)
- TRPC1
- Hippocampus
- ER homeostasis
- TRPC ligands