Medizinische Universität Graz - Research portal
Selected Publication:
SHR Neuro Cancer Cardio Lipid Metab Microb
Fandler-Höfler, S; Ambler, G; Banerjee, G; Nash, PS; Obergottsberger, L; Wünsch, G; Kiss, C; Fabisch, L; Kneihsl, M; Zhang, W; Ozkan, H; Locatelli, M; Du, Y; Panteleienko, L; Mendel, R; Thiankhaw, K; Simister, RJ; Jäger, HR; Enzinger, C; Gattringer, T; Werring, DJ.
Temporal and Spatial Clustering of Intracerebral Hemorrhage in Cerebral Amyloid Angiopathy.
Neurology. 2024; 103(5): e209770
Doi: 10.1212/WNL.0000000000209770
[OPEN ACCESS]
Web of Science
PubMed
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- Leading authors Med Uni Graz
- Fandler-Höfler Simon
- Co-authors Med Uni Graz
- Enzinger Christian
- Fabisch Linda
- Gattringer Thomas
- Kiss Christian
- Kneihsl Markus
- Wünsch Gerit
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- Abstract:
- OBJECTIVES: Cerebral amyloid angiopathy (CAA)-associated lobar intracerebral hemorrhage (ICH) has a high risk of recurrence, but the underlying mechanisms remain uncertain. We, therefore, aimed to characterize patterns of recurrent ICH. METHODS: We investigated early recurrent ICH (≥1 recurrent ICH event within 90 days of the index event) and ICH clusters (≥2 ICH events within 90 days at any time point) in 2 large cohorts of consecutive patients with first-ever ICH and available MRI. RESULTS: In 682 included patients (median age 68 years, 40.3% female, median follow-up time 4.1 years), 18 (2.6%) had an early recurrent ICH, which was associated with higher age and CAA. In patients with probable CAA, the risk of early recurrent ICH was increased 5-fold within the first 3 months compared with during months 4-12 (hazard ratio 5.41, 95% CI 2.18-13.4) while no significant difference was observed in patients without CAA. In patients with an ICH cluster, we observed spatial clustering (recurrent ICH within close proximity of index ICH in 63.0%) and a tendency for multiple sequential hemorrhages (≥3 ICH foci within 3 months in 44.4%). DISCUSSION: Our data provide evidence of both temporal and spatial clustering of ICH in CAA, suggesting a transient and localized active bleeding-prone process.
- Find related publications in this database (using NLM MeSH Indexing)
- Humans - administration & dosage
- Cerebral Amyloid Angiopathy - complications, diagnostic imaging, epidemiology
- Female - administration & dosage
- Male - administration & dosage
- Cerebral Hemorrhage - diagnostic imaging, epidemiology
- Aged - administration & dosage
- Recurrence - administration & dosage
- Middle Aged - administration & dosage
- Magnetic Resonance Imaging - administration & dosage
- Aged, 80 and over - administration & dosage
- Cohort Studies - administration & dosage
- Follow-Up Studies - administration & dosage
- Time Factors - administration & dosage
- Cluster Analysis - administration & dosage