Medizinische Universität Graz - Research portal
Selected Publication:
SHR Neuro Cancer Cardio Lipid Metab Microb
Westphal, T; Rinnerthaler, G; Gampenrieder, SP; Niebauer, J; Thaler, J; Pfob, M; Fuchs, D; Riedmann, M; Mayr, B; Reich, B; Melchardt, T; Mlineritsch, B; Pleyer, L; Greil, R.
Supervised versus autonomous exercise training in breast cancer patients: A multicenter randomized clinical trial.
Cancer Med. 2018; 7(12): 5962-5972.
Doi: 10.1002/cam4.1851
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- Co-authors Med Uni Graz
- Rinnerthaler Gabriel
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- Abstract:
- BACKGROUND: There is a well-known correlation between obesity, sedentary lifestyle, and breast cancer incidence and outcome. The Arbeitsgemeinschaft Medikamentöse Tumortherapie (AGMT) exercise study was a multicenter, randomized clinical trial and assessed the feasibility and efficacy of physical training in 50 breast cancer patients undergoing aromatase inhibitor treatment. METHODS: Postmenopausal, estrogen receptor-positive breast cancer patients under aromatase inhibitor treatment were randomized 1:1 to counseling and unsupervised training for 48 weeks (unsupervised arm) or counseling and a sequential training (supervised arm) with a supervised phase (24 weeks) followed by unsupervised physical training (further 24 weeks). Primary endpoint was the individual maximum power output on a cycle ergometer after 24 weeks of exercise. A key secondary endpoint was the feasibility of achieving 12 METh/week (metabolic equivalent of task hours per week). RESULTS: Twenty-three patients (92%) in the unsupervised arm and 19 patients (76%) in the supervised arm with early-stage breast cancer completed the study. After 24 weeks, the supervised arm achieved a significantly higher maximum output in watt (mean 132 ± standard deviation [SD] 34; 95% confidence interval [CI] 117-147) compared to baseline (107 ± 25; 95%CI 97-117; P = 0.012) with a numerically higher output than the unsupervised arm (week 24 115 ± 25; 95%CI 105-125; P = 0.059). Significantly higher METh/week was reported in the supervised arm compared to the unsupervised arm during the whole study period (week 1-24 unsupervised: 18.3 (7.6-58.3); supervised: 28.5 (6.7-40.1); P = 0.043; week 25-48; P = 0.041)). CONCLUSION: This trial indicates that patients in an exercise program achieve higher fitness levels during supervised than unsupervised training.
- Find related publications in this database (using NLM MeSH Indexing)
- Aged - administration & dosage
- Aged, 80 and over - administration & dosage
- Aromatase Inhibitors - therapeutic use
- Breast Neoplasms - therapy
- Exercise - administration & dosage
- Exercise Therapy - methods
- Female - administration & dosage
- Humans - administration & dosage
- Middle Aged - administration & dosage
- Patient Compliance - administration & dosage
- Find related publications in this database (Keywords)
- breast cancer
- early
- endocrine therapy
- exercise
- postmenopausal