Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Kickinger, S; Stattin, M; Haas, AM; Ahmed-Balestra, D; Jacob, M; Zehetner, C; Krepler, K; Ansari-Shahrezaei, S.
Comparison between indocyanine green angiography and optical coherence tomography angiography for the detection of nonexudative macular neovascularization.
Graefes Arch Clin Exp Ophthalmol. 2024;
Doi: 10.1007/s00417-024-06597-5
Web of Science
PubMed
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- Führende Autor*innen der Med Uni Graz
- Ansari Shahrezaei Siamak
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- Abstract:
- PURPOSE: Patients with unilateral treatment-naïve exudative neovascular age-related macular degeneration (nAMD) were examined for the presence of nonexudative macular neovascularization (neMNV) in their fellow eye using a multimodal imaging approach. This is intended to determine the sensitivity of individual imaging methods, namely, indocyanine green angiography (ICGA) and optical coherence tomography angiography (OCTA). METHODS: In this retrospective cross-sectional study, ICGA images of the nonexudative eye were analyzed for the presence of plaques. SS-OCTA outer retinal segmentations were evaluated for neovascular flow in en-face scans and/or color-coded flow in B-scans. The findings were matched with a double-layer sign (DLS) or pigment epithelium detachment (PED) on conventional OCT. RESULTS: In total, neMNV was diagnosed in the fellow eye of 40 of 241 patients (17%) using a multimodal imaging approach employing both ICGA and SS-OCTA. 25 eyes (10%) showed neMNV in both modalities, while 7 (3%) were only detected by ICGA and 8 (3%) by OCTA alone. The sensitivities of ICGA therefore were 80% (32/40) and 83% (33/40) for OCTA. Of the 40 eyes with neMNV, OCT revealed DLS in 25/40 (63%) and PED in 17/40 (43%) of the cases. CONCLUSION: None of the modalities alone could detect all neMNV in the partner eye of Caucasians with unilateral treatment-naïve exudative nAMD. ICGA and OCTA showed comparable sensitivity. The combination of ICGA, OCTA, and OCT provides the most comprehensive screening for this AMD subtype.
- Find related publications in this database (Keywords)
- Age-related macular degeneration
- Indocyanine green angiography
- Nonexudative
- Optical coherence tomography angiography