Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Tuca, AC; Bernardelli, de, Mattos, I; Funk, M; Markovic, D; Winter, R; Lemarchand, T; Kniepeiss, D; Spendel, S; Hartmann, B; Ottoman, C; Kamolz, LP.
A Standardized Porcine Model for Partial-Thickness Wound Healing Studies: Design, Characterization, Model Validation, and Histological Insights.
Int J Mol Sci. 2024; 25(14): 7658
Doi: 10.3390/ijms25147658
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- Führende Autor*innen der Med Uni Graz
- Tuca Alexandru
- Co-Autor*innen der Med Uni Graz
- Kamolz Lars-Peter
- Kniepeiss Daniela
- Markovic Danijel
- Spendel Stephan
- Winter Raimund
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- Abstract:
- Wound healing is a complex process that is still not fully understood despite extensive research. To address this, we aimed to design and characterize a standardized porcine model for the evaluation of wound healing, dressings, cell therapies, and pharmaceutical agents. Using a standardized approach, we examined the wound healing process in 1.2 mm-deep dermatome wounds at defined positions in 11 female pigs. Unlike previous studies that have only described/analyzed selected punch biopsies, we performed and described histological analyses along the complete wound length using quantitative morphometric methods. All animals remained fully healthy following surgery and showed no signs of infection. Our histopathological evaluation using a predetermined grading score and quantitative manual morphometry demonstrated the impact of different tissue sampling methods, sampling sites, and residual dermis thickness on wound healing. Our study presents a reproducible model for wound healing evaluation and demonstrates the usefulness of porcine models for assessing dermal and epidermal wound healing. The use of histological analyses over the complete wound length provides advantages over previous studies, leading to the possibility of a deeper understanding of the wound healing process. This model could potentially facilitate future research on novel wound dressings and local wound healing therapies.
- Find related publications in this database (using NLM MeSH Indexing)
- Animals - administration & dosage
- Wound Healing - administration & dosage
- Swine - administration & dosage
- Female - administration & dosage
- Disease Models, Animal - administration & dosage
- Skin - pathology, injuries
- Dermis - pathology
- Bandages - administration & dosage
- Find related publications in this database (Keywords)
- wound healing
- animal models
- histology
- porcine model