Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Arabi, TZ; Fakhoury, HMA; Tamim, H; Chun, RF; Hewison, M; AlAnouti, F; Pilz, S; Annweiler, C; Tzimagiorgis, G; Haitoglou, C; Karras, SN.
Associations between total, free and bioavailable 25-hydroxyvitamin D forms with adiponectin and irisin in maternal-neonatal pairs at birth from Greece.
Front Endocrinol (Lausanne). 2024; 15: 1397869
Doi: 10.3389/fendo.2024.1397869
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- Co-Autor*innen der Med Uni Graz
- Pilz Stefan
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- Abstract:
- BACKGROUND: Apart from the well-established skeletal effects, vitamin D has been explored as a secretagogue influencing various adipokines, including adiponectin and irisin. Recent evidence suggests that specific forms of 25-Hydroxyvitamin D (25(OHD), such as free and bioavailable 25(OH)D, may provide more accurate measurements of vitamin D status. The relationship between vitamin D status and serum irisin and adiponectin concentrations remains largely unexplored, particularly during pregnancy. METHODS: We analyzed data from 67 healthy maternal-neonatal pairs from Northern Greece at birth. Biochemical and hormonal tests were conducted on each maternal-neonatal pair. The vitamin D forms were estimated using validated mathematical models. Subsequently, regression analyses were conducted to determine the association between the vitamin D forms and adipokine levels. RESULTS: Bioavailable maternal 25(OH)D was inversely associated with neonatal irisin concentrations [β=-73.46 (-140.573 to -6.341), p=0.034]. No other associations were observed between maternal vitamin D status and neonatal adipokine concentrations. CONCLUSION: In conclusion, maternal bioavailable vitamin D concentrations are inversely associated with neonatal serum irisin concentrations, warranting further studies to evaluate the underlying mechanisms for this finding.
- Find related publications in this database (using NLM MeSH Indexing)
- Humans - administration & dosage
- Fibronectins - blood
- Female - administration & dosage
- Vitamin D - blood, analogs & derivatives
- Adiponectin - blood
- Greece - administration & dosage
- Pregnancy - administration & dosage
- Infant, Newborn - administration & dosage
- Adult - administration & dosage
- Male - administration & dosage
- Find related publications in this database (Keywords)
- vitamin D
- adiponectin
- irisin
- neonatal
- maternal
- free vitamin D
- bioavailable vitamin D2