Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Sastre-Garriga, J; Vidal-Jordana, A; Toosy, AT; Enzinger, C; Granziera, C; Frederiksen, J; Ciccarelli, O; Filippi, M; Montalban, X; Tintore, M; Pareto, D; Rovira, À, , MAGNIMS, Study, Group.
Value of Optic Nerve MRI in Multiple Sclerosis Clinical Management: A MAGNIMS Position Paper and Future Perspectives.
Neurology. 2024; 103(3):e209677
Doi: 10.1212/WNL.0000000000209677
[OPEN ACCESS]
Web of Science
PubMed
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- Co-Autor*innen der Med Uni Graz
- Enzinger Christian
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- Abstract:
- The optic nerve is frequently involved in multiple sclerosis (MS). However, MRI of the optic nerve is considered optional in the differential diagnosis of optic neuropathy symptoms either at presentation or in established MS. In addition, unlike spinal cord imaging in comparable scenarios, no role is currently recommended for optic nerve MRI in patients presenting with optic neuritis for its confirmation, to plan therapeutic strategy, within the MS diagnostic framework, nor for the detection of subclinical activity in established MS. In this article, evidence related to these 3 aspects will be summarized and gaps in knowledge will be highlighted, including (1) the acquisition challenges and novel sequences that assess pathologic changes within the anterior visual pathways; (2) the clinical implications of quantitative magnetic resonance studies of the optic nerve, focusing on atrophy measures, magnetization transfer, and diffusion tensor imaging; and (3) the relevant clinical studies performed to date. Finally, an algorithm for the application of optic nerve MRI will be proposed to guide future studies aimed at addressing our knowledge gaps.
- Find related publications in this database (using NLM MeSH Indexing)
- Humans - administration & dosage
- Multiple Sclerosis - diagnostic imaging, therapy
- Magnetic Resonance Imaging - methods
- Optic Nerve - diagnostic imaging, pathology
- Optic Neuritis - diagnostic imaging, therapy
- Disease Management - administration & dosage