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SHR Neuro Cancer Cardio Lipid Metab Microb

Kicheeva, AG; Sushko, ES; Bondarenko, LS; Baimuratova, RK; Kydralieva, KA; Schwaminger, SP; Prassl, R; Tropskaya, NS; Dzhardimalieva, GI; Smirnykh, DV; Martynova, AA; Kudryasheva, NS.
Cytotoxic and radical activities of metal-organic framework modified with iron oxide: Biological and physico-chemical analyses.
Chem Biol Interact. 2024; 399:111150 Doi: 10.1016/j.cbi.2024.111150
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Co-authors Med Uni Graz: Prassl Ruth; Schwaminger Sebastian
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Abstract:: Metal-organic framework (MOF) modified with iron oxide, Fe₃O₄-MOF, is a perspective drug delivery agent, enabling magnetic control and production of active hydroxyl radicals, •OH, via the Fenton reaction. This paper studies cytotoxic and radical activities of Fe-containing nanoparticles (NPs): Fe₃O₄-MOF and its components - bare Fe₃O₄ and MOF (MIL-88B). Luminous marine bacteria Photobacteriumphosphoreum were used as a model cellular system to monitor bioeffects of the NPs. Neither the NPs of Fe₃O₄-MOF nor MOF showed cytotoxic effects in a wide range of concentrations (<10 mg/L); while Fe₃O₄ was toxic at >3·10^-3 mg/L. The NPs of Fe₃O₄ did not affect the bacterial bioluminescence enzymatic system; their toxic effect was attributed to cellular membrane processes. The integral content of reactive oxygen species (ROS) was determined using a chemiluminescence luminol assay. Bacteria mitigated excess of ROS in water suspensions of Fe₃O₄-MOF and MOF, maintaining bioluminescence intensity closer to the control; this resulted in low toxicity of these NPs. We estimated the activity of •OH radicals in the NPs samples with physical and chemical methods - spin capture technology (using electron paramagnetic resonance spectroscopy) and methylene blue degradation. Physico-chemical interpretation of cellular responses is provided in terms of iron content, iron ions release and •OH radical production.
Find related publications in this database (using NLM MeSH Indexing): Metal-Organic Frameworks - chemistry, pharmacology; Photobacterium - drug effects; Ferric Compounds - chemistry; Hydroxyl Radical - chemistry, metabolism; Reactive Oxygen Species - metabolism; Electron Spin Resonance Spectroscopy - administration & dosage; Cell Survival - drug effects
Find related publications in this database (Keywords): Metal organic frameworks; Magnetite nanoparticles; Reactive oxygen species; Toxicity; Bacteria bioluminescence assay; Ferroptosis