Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Gucer, F; Tamussino, K; Panzitt, T; Taucher, A; Haas, J; Petru, E; Winter, R.
Prognostic Implications of Thrombocytosis in Patients with Stage-III and Stage-IV Cervical-Cancer
INT J GYNECOL CANCER 1998 8: 369-373.
Doi: 10.1046/j.1525-1438.1998.09851.x
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- Führende Autor*innen der Med Uni Graz
- Tamussino Karl
- Co-Autor*innen der Med Uni Graz
- Haas Josef
- Petru Edgar
- Winter Raimund
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- Abstract:
- The purpose of this study was to evaluate the prognostic significance of thrombocytosis in patients with advanced (stage I:II and IV) cervical cancer. A total of 128 patients without conditions associated with thrombocytosis who received a diagnosis of stage III or IV cervical carcinoma at our department between 1985 and 1993 were included in the study. Thrombocytosis was defined as a platelet count above 400,000/mu l Ninety-two of 128 patients (72%) had stage III and 36 (28%) had stage IV disease. Squamous cell carcinomas accounted for 109 (85%) of the carcinomas. Median follow-up was 11 months (range 1-106 months). Thrombocytosis was present in 33 of 128 (26%) patients. The mean pretreatment platelet count +/- standard deviation (SD) was 345,000 +/- 135,000. The estimated overall five-year survival rate was 16%. The five-year survival rate of the 33 patients with thrombocytosis was significantly worse than that of the 95 patients with a platelet count <400,000/mu l (3.5% vs 22%, P = 0.035). In patients with stage III disease and thrombocytosis, the five-year survival rate was significantly lower than in those without thrombocytosis (5% vs 26%, P = 0.036). In stage IV patients, there was no significant difference (0% vs 6%, P > 0.05). In multivariate analysis, age, hemoglobin, and treatment (vs palliation) were significantly associated with prognosis, whereas thrombocytosis was not. Thrombocytosis is not an independent prognostic factor in advanced stage cervical cancer.
- Find related publications in this database (Keywords)
- Cervical Cancer
- Hemoglobin
- Platelet Count
- Prognosis
- Thrombocytosis