Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Rosen, AC; Graf, AH; Hacker, GW; Klein, M; Lahousen, M; Vavra, N; Reiner, A.
Prognostic impact of DNA content and AUER classification in primary fallopian tube carcinoma.
Cancer Lett. 1995; 92(1):97-103
Doi: 10.1016%2F0304-3835%2895%2903760-T
Web of Science
PubMed
FullText
FullText_MUG
Google Scholar
- Co-Autor*innen der Med Uni Graz
- Lahousen Manfred
- Altmetrics:
- Dimensions Citations:
- Plum Analytics:
- Scite (citation analytics):
- Abstract:
- DNA ploidy has been studied in 61 primary fallopian tube carcinomas using image-cytometry. The investigation also included survival analysis, and ploidy classification according to AUER was performed in order to evaluate its prognostic impact for fallopian tube carcinoma. A high number of aneuploid cases were observed (79% aneuploid vs. 21% euploid tumors). The high incidence of aneuploid tumors was consistently observed among all FIGO-stages as well as all groups of histologic grading. There was no correlation between ploidy and FIGO-stage or histologic grading. Patients with euploid DNA content showed a median survival of 34 months compared to 24 months for aneuploid cases (log-rank, P = 0.83). No correlation between the AUER classification and FIGO-stage or histologic grading could be observed. Tumors with an AUER type I and II (75th quantile 41 months) showed a better outcome than tumors with AUER III and IV (75th quantile 19 months). Although these results did not reach statistical significance (P = 0.07), a trend could be observed. Therefore AUER classification may be useful as an objective prognostic parameter. The high incidence of aneuploid tumors could be an expression of the high biologic aggressiveness of primary fallopian tube cancer which has been repeatedly mentioned in the past.
- Find related publications in this database (using NLM MeSH Indexing)
- Adenocarcinoma - classification
- Adult - classification
- Aged - classification
- DNA, Neoplasm - analysis
- Fallopian Tube Neoplasms - classification
- Female - classification
- Humans - classification
- Middle Aged - classification
- Neoplasm Staging - classification
- Ploidies - classification
- Prognosis - classification
- Survival Analysis - classification
- Find related publications in this database (Keywords)
- DNA Ploidy
- Fallopian Tube Cancer
- Auer Classification