Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Mooslechner, AA; Schuller, M; Pfeifer, V; Klötzer, KA; Prietl, B; Kirsch, AH; Stiegler, P; Sucher, R; Sourij, H; Rosenkranz, AR; Eller, K.
Pre-Transplant Frequencies of FoxP3+CD25+ in CD3+CD8+ T Cells as Potential Predictors for CMV in CMV-Intermediate Risk Kidney Transplant Recipients.
Transpl Int. 2024; 37: 12963
Doi: 10.3389/ti.2024.12963
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- Führende Autor*innen der Med Uni Graz
- Eller Kathrin
- Mooslechner Agnes Anna
- Schuller Max
- Co-Autor*innen der Med Uni Graz
- Kirsch Alexander
- Klötzer Konstantin Adrian
- Pfeifer Verena
- Prietl Barbara
- Rosenkranz Alexander
- Sourij Harald
- Stiegler Philipp
- Sucher Robert
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- Abstract:
- Cytomegalovirus (CMV) infection detrimentally influences graft survival in kidney transplant recipients, with the risk primarily determined by recipient and donor serostatus. However, recipient CD8+ T cells play a crucial role in CMV control. The optimal preventive strategy (prophylaxis vs. pre-emptive treatment), particularly for seropositive (intermediate risk) recipients, remains uncertain. We investigated CD8+ T cell subpopulation dynamics and CMV occurrence (DNAemia ≥ 100 IU/mL) in 65 kidney transplant recipients, collecting peripheral blood mononuclear cells before (T1) and 1 year after transplantation (T2). Comparing the two timepoints, we found an increase in granulocyte, monocyte and CD3+CD8+ T cells numbers, while FoxP3+CD25+, LAG-3+ and PD-1+ frequencies were reduced at T2. CMV DNAemia occurred in 33 recipients (55.8%) during the first year. Intermediate risk patients were disproportionally affected by posttransplant CMV (N = 29/45, 64.4%). Intermediate risk recipients developing CMV after transplantation exhibited lower leukocyte, monocyte, and granulocyte counts and higher FoxP3+CD25+ frequencies in CD3+CD8+ T cells pre-transplantation compared to patients staying CMV negative. Pre-transplant FoxP3+CD25+ in CD3+CD8+ T cells had the best discriminatory potential for CMV infection prediction within the first year after transplantation (AUC: 0.746). The FoxP3+CD25+ CD3+CD8+ T cell subset may aid in selecting intermediate risk kidney transplant recipients for CMV prophylaxis.
- Find related publications in this database (using NLM MeSH Indexing)
- Humans - administration & dosage
- Kidney Transplantation - adverse effects
- Cytomegalovirus Infections - immunology, prevention & control
- Female - administration & dosage
- Male - administration & dosage
- CD8-Positive T-Lymphocytes - immunology
- Middle Aged - administration & dosage
- Forkhead Transcription Factors - metabolism
- Adult - administration & dosage
- Interleukin-2 Receptor alpha Subunit - metabolism
- Aged - administration & dosage
- CD3 Complex - metabolism
- Cytomegalovirus - immunology
- Risk Factors - administration & dosage
- Transplant Recipients - administration & dosage
- Graft Survival - immunology
- Find related publications in this database (Keywords)
- kidney transplant
- biomarker
- cytomegalovirus management
- immune cells
- valganciclovir