Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Zanghellini, B; Zechmann, N; Baurecht, D; Grünewald, TA; Burghammer, M; Liegl-Atzwanger, B; Leithner, A; Davydok, A; Lichtenegger, H.
Multimodal analysis and comparison of stoichiometric and structural characteristics of parosteal and conventional osteosarcoma with massive sclerosis in human bone.
J Struct Biol. 2024; 216(3): 108106
Doi: 10.1016/j.jsb.2024.108106
Web of Science
PubMed
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- Co-Autor*innen der Med Uni Graz
- Leithner Andreas
- Liegl-Atzwanger Bernadette
- Zechmann Nicole
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- Abstract:
- Osteosarcoma (OS) is the most common malignant primary bone tumor in humans and occurs in various subtypes. Tumor formation happens through malignant osteoblasts producing immature bone. In the present paper we studied two different subtypes of osteosarcoma, from one individual with conventional OS with massive sclerosis and one individual with parosteal OS, based on a multimodal approach including small angle x-ray scattering (SAXS), wide angle x-ray diffraction (WAXS), backscattered electron imaging (BEI) and Raman spectroscopy. It was found that both tumors showed reduced mineral particle sizes and degree of orientation of the collagen-mineral composite in the affected areas, alongside with a decreased crystallinity. Distinct differences between the tumor material from the two individuals were found in the degree of mineralization. Further differences were observed in the carbonate to phosphate ratio, which is related to the degree of carbonate substitution in bone mineral and indicative of the turnover rate. The contraction of the c-axis of the bone mineral crystals proved to be a further, very sensitive parameter, potentially indicative of malignancy.
- Find related publications in this database (using NLM MeSH Indexing)
- Humans - administration & dosage
- Osteosarcoma - pathology, metabolism
- X-Ray Diffraction - methods
- Spectrum Analysis, Raman - methods
- Scattering, Small Angle - administration & dosage
- Bone Neoplasms - pathology
- Sclerosis - pathology
- Bone and Bones - pathology
- Male - administration & dosage
- Female - administration & dosage
- Find related publications in this database (Keywords)
- Bone
- Osteosarcoma
- Crystal structure
- Carbonate substitution
- Raman spectroscopy
- X-ray diffraction