Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Ashour, D; Le, Gouge, K; Rainer, PP; Mariotti-Ferrandiz, E; Campos, Ramos, G.
Exploring T Cell Receptor Repertoires in Myocardial Diseases.
Circ Res. 2024; 134(12):1808-1823
Doi: 10.1161/CIRCRESAHA.124.323661
Web of Science
PubMed
FullText
FullText_MUG
- Führende Autor*innen der Med Uni Graz
- Rainer Peter
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- Abstract:
- Mounting experimental and clinical evidence has revealed that adaptive immune mechanisms targeting myocardial antigens are triggered by different forms of cardiac injury and impact disease progression. B and T lymphocytes recognize specific antigens via unique adaptive immune receptors generated through a somatic rearrangement process that generates a potential repertoire of 1019 unique receptors. While the adaptive immune receptor repertoire diversity provides the basis for immunologic specificity, making sense of it can be a challenging task. In the present review, we discuss key aspects underlying the generation of TCRs (T cell receptors) and emerging tools for their study in the context of myocardial diseases. Moreover, we outline how exploring TCR repertoires could lead to a deeper understanding of myocardial pathophysiological principles and potentially serve as diagnostic tools.
- Find related publications in this database (using NLM MeSH Indexing)
- Humans - administration & dosage
- Receptors, Antigen, T-Cell - immunology, metabolism
- Animals - administration & dosage
- Cardiomyopathies - immunology, genetics, metabolism
- Adaptive Immunity - administration & dosage
- T-Lymphocytes - immunology, metabolism
- Myocardium - metabolism, immunology, pathology
- Find related publications in this database (Keywords)
- antigens
- heart failure
- inflammation
- myocardium
- T-lymphocytes