Medizinische Universität Graz - Research portal
Selected Publication:
SHR Neuro Cancer Cardio Lipid Metab Microb
Fruhwirth, V; Berger, L; Gattringer, T; Fandler-Höfler, S; Kneihsl, M; Eppinger, S; Ropele, S; Fink, A; Deutschmann, H; Reishofer, G; Enzinger, C; Pinter, D.
White matter integrity and functional connectivity of the default mode network in acute stroke are associated with cognitive outcome three months post-stroke.
J Neurol Sci. 2024; 462: 123071
Doi: 10.1016/j.jns.2024.123071
Web of Science
PubMed
FullText
FullText_MUG
- Leading authors Med Uni Graz
- Fruhwirth Viktoria Maria
- Pinter Daniela Theresia
- Co-authors Med Uni Graz
- Berger Lisa
- Deutschmann Hannes
- Enzinger Christian
- Eppinger Sebastian
- Fandler-Höfler Simon
- Gattringer Thomas
- Kneihsl Markus
- Reishofer Gernot
- Ropele Stefan
- Altmetrics:
- Dimensions Citations:
- Plum Analytics:
- Scite (citation analytics):
- Abstract:
- BACKGROUND: Knowledge about factors that are associated with post-stroke cognitive outcome is important to identify patients with high risk for impairment. We therefore investigated the associations of white matter integrity and functional connectivity (FC) within the brain's default-mode network (DMN) in acute stroke patients with cognitive outcome three months post-stroke. METHODS: Patients aged between 18 and 85 years with an acute symptomatic MRI-proven unilateral ischemic middle cerebral artery infarction, who had received reperfusion therapy, were invited to participate in this longitudinal study. All patients underwent brain MRI within 24-72 h after symptom onset, and participated in a neuropsychological assessment three months post-stroke. We performed hierarchical regression analyses to explore the incremental value of baseline white matter integrity and FC beyond demographic, clinical, and macrostructural information for cognitive outcome. RESULTS: The study cohort comprised 34 patients (mean age: 64 ± 12 years, 35% female). The initial median National Institutes of Health Stroke Scale (NIHSS) score was 10, and significantly improved three months post-stroke to a median NIHSS = 1 (p < .001). Nonetheless, 50% of patients showed cognitive impairment three months post-stroke. FC of the non-lesioned anterior cingulate cortex of the affected hemisphere explained 15% of incremental variance for processing speed (p = .007), and fractional anisotropy of the non-lesioned cingulum of the affected hemisphere explained 13% of incremental variance for cognitive flexibility (p = .033). CONCLUSIONS: White matter integrity and functional MRI markers of the DMN in acute stroke explain incremental variance for post-stroke cognitive outcome beyond demographic, clinical, and macrostructural information.
- Find related publications in this database (using NLM MeSH Indexing)
- Humans - administration & dosage
- Female - administration & dosage
- Male - administration & dosage
- Middle Aged - administration & dosage
- Aged - administration & dosage
- White Matter - diagnostic imaging, pathology
- Stroke - diagnostic imaging, complications, physiopathology
- Aged, 80 and over - administration & dosage
- Magnetic Resonance Imaging - administration & dosage
- Default Mode Network - diagnostic imaging, physiopathology
- Adult - administration & dosage
- Longitudinal Studies - administration & dosage
- Neuropsychological Tests - administration & dosage
- Cognitive Dysfunction - etiology, diagnostic imaging, physiopathology
- Young Adult - administration & dosage
- Adolescent - administration & dosage
- Brain - diagnostic imaging, physiopathology, pathology
- Neural Pathways - diagnostic imaging, physiopathology
- Find related publications in this database (Keywords)
- Stroke
- Cognition
- MRI
- Default mode network
- Longitudinal