Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Obermayer-Pietsch, B; Fössl, I; Thomasius, F.
Positive and Negative (Side)Effects of Osteoporosis-Specific Sequential Therapy
OSTEOLOGIE. 2024; 33(02): 80-87.
Doi: 10.1055/a-2254-0454
Web of Science
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- Führende Autor*innen der Med Uni Graz
- Obermayer-Pietsch Barbara
- Co-Autor*innen der Med Uni Graz
- Fößl Ines
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- Abstract:
- Indications and procedures around pharmacological options for osteoporosis therapeutics have been reviewed during the past years. Besides well-known therapeutic effects on bone metabolism, structure and fracture risk, several positive effects outside the bone have been recorded; however, also a number of rare, but serious side effects caused by bone-active medication. Positive effects were recorded for beneficial impacts on cardiovascular events, reduced incidences for carcinomas and reduced mortality, but also reduced infection and hospitalisation rates for COVID with sufficient baseline therapies. However, antiresorptive therapies may have rare, but severe side effects - e. g., atypical femoral fractures (AFF), occurring in 0.02% of cases, mostly during long-standing treatments. Widely noticed side effects are "Medication-Related OsteoNecroses of the Jaw" bone (MRONJ), mainly related to high and long-standing doses of antiresorptive medication applied for oncological reasons, while occurring in 0.001%-0.01% of osteoporosis patients. Eye-related symptoms (BROSE, ,,Bisphosphonat-Related Ocular Side Effects"), have been described in some twenty cases worldwide. In this review, descriptions and mechanisms about side effects of osteoporosis medication are summarized also for special patient groups. New developments including sequential therapy as well as prophylactic measures are described.
- Find related publications in this database (Keywords)
- Osteoporosis
- Therapy
- Side effects
- Risk factors