Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Fössl, I; Obermayer-Pietsch, B.
An Introduction to Current and Future Pharmacological Therapy Options and their Mechanisms of Action
OSTEOLOGIE. 2024; 33(02): 67-73.
Doi: 10.1055/a-2304-7012
Web of Science
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- Führende Autor*innen der Med Uni Graz
- Fößl Ines
- Co-Autor*innen der Med Uni Graz
- Obermayer-Pietsch Barbara
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- Abstract:
- Currently available pharmacological therapies for the treatment of osteoporosis pursue either an antiresorptive or osteoanabolic approach or have a dual effect. Antiresorptive therapies (bisphosphonates, denosumab, oestrogens and selective oestrogen receptor modulators (SERMs)) increase bone mass by inhibiting bone resorption. Osteoanabolic therapies (teriparatide and abaloparatide) increase bone mass by stimulating bone formation. Romosozumab is considered to have a dual effect. This review article presents the current pharmacological therapy options for osteoporosis treatment and their mechanisms of action. In addition, new treatment approaches are discussed, such as the use of mesenchymal stem cells (MSCs), extracellular vesicles (EVs), the blocking of follicle-stimulating hormone (FSH) and individualised adjustment of the bisphosphonate dose.
- Find related publications in this database (Keywords)
- osteoporosis
- antiresorptive therapy
- osteoanabolic therapy
- mechanism of action