Medizinische Universität Graz - Research portal
Selected Publication:
SHR Neuro Cancer Cardio Lipid Metab Microb
Skaarup, KG; Lassen, MCH; Modin, D; Johansen, ND; Loiacono, MM; Harris, RC; Lee, JKH; Dufournet, M; Vardeny, O; Peikert, A; Claggett, B; Solomon, SD; Jensen, JUS; Biering-Sørensen, T.
The relative vaccine effectiveness of high-dose vs standard-dose influenza vaccines in preventing hospitalization and mortality: A meta-analysis of evidence from randomized trials.
J Infect. 2024; 89(1):106187
Doi: 10.1016/j.jinf.2024.106187
Web of Science
PubMed
FullText
FullText_MUG
- Co-authors Med Uni Graz
- Peikert Alexander
- Altmetrics:
- Dimensions Citations:
- Plum Analytics:
- Scite (citation analytics):
- Abstract:
- OBJECTIVES: To summarize current evidence of high-dose influenza vaccine (HD-IV) vs standard-dose (SD-IV) regarding severe clinical outcomes. METHODS: A prespecified meta-analysis was conducted to assess relative vaccine effectiveness (rVE) of HD-IV vs SD-IV in reducing the rates of (1) pneumonia and influenza (P&I) hospitalization, (2) all hospitalizations, and (3) all-cause death in adults ≥ 65 years in randomized controlled trials. Pooled effect sizes were estimated using fixed-effects models with the inverse variance method. RESULTS: Five randomized trials were included encompassing 105,685 individuals. HD-IV vs SD-IV reduced P&I hospitalizations (rVE: 23.5 %, [95 %CI: 12.3 to 33.2]). HD-IV vs SD-IV also reduced rate of all-cause hospitalizations (rVE: 7.3 %, [95 %CI: 4.5 to 10.0]). No significant differences were observed in death rates (rVE = 1.6 % ([95 %CI: -2.0 to 5.0]) in HD-IV vs SD-IV. Sensitivity analyses omitting trials with participants sharing the same comorbidity, trials with ≥ 100 events, and random-effects models provided comparable estimates for all outcomes. CONCLUSIONS: HD-IV reduced the incidence of P&I and all-cause hospitalization vs SD-IV in adults ≥ 65 years in randomized trials, through no significant difference was observed in all-cause death rates. These findings, supported by evidence from several randomized studies, can benefit from replication in a fully powered, individually randomized trial.
- Find related publications in this database (using NLM MeSH Indexing)
- Humans - administration & dosage
- Hospitalization - statistics & numerical data
- Influenza Vaccines - administration & dosage, immunology
- Influenza, Human - prevention & control, mortality
- Randomized Controlled Trials as Topic - administration & dosage
- Aged - administration & dosage
- Vaccine Efficacy - administration & dosage
- Pneumonia - prevention & control, mortality
- Male - administration & dosage
- Aged, 80 and over - administration & dosage
- Female - administration & dosage
- Find related publications in this database (Keywords)
- High -dose influenza vaccine
- Randomized trials
- Meta -analysis
- Severe clinical endpoints