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SHR Neuro Cancer Cardio Lipid Metab Microb

Bierewirtz, T; Narayanaswamy, K; Giuffrida, R; Rese, T; Bortis, D; Zimpfer, D; Kolar, JW; Kertzscher, U; Granegger, M.
A Novel Pumping Principle for a Total Artificial Heart
IEEE T BIO-MED ENG. 2024; 71(2): 446-455. Doi: 10.1109/TBME.2023.3306888
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Co-authors Med Uni Graz: Zimpfer Daniel
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Abstract:: Objective: Total artificial hearts (TAH) serve as a temporary treatment for severe biventricular heart failure. The limited durability and complication rates of current devices hamper long-term cardiac replacement. The aim of this study was to assess the feasibility of a novel valveless pumping principle for a durable pulsatile TAH (ShuttlePump). Methods: The pump features a rotating and linearly shuttling piston within a cylindrical housing with two in- and outlets. With a single moving piston, the ShuttlePump delivers pulsatile flow to both systemic and pulmonary circulation. The pump and actuation system were designed iteratively based on analytical and in silico methods, utilizing finite element methods (FEM) and computational fluid dynamics (CFD). Pump characteristics were evaluated experimentally in a mock circulation loop mimicking the cardiovascular system, while hemocompatibility-related parameters were calculated numerically. Results: Pump characteristics cover the entire required operating range for a TAH, providing 2.5-9 L/min of flow rate against 50-160 mmHg arterial pressures at stroke frequencies of 1.5-5 Hz while balancing left and right atrial pressures. FEM analysis showed mean overall copper losses of 8.84 W, resulting in a local maximum blood temperature rise of <2 K. The CFD results of the normalized index of hemolysis were 3.57 mg/100 L, and 95% of the pump's blood volume was exchanged after 1.42 s. Conclusion and significance: This study indicates the feasibility of a novel pumping system for a TAH with numerical and experimental results substantiating further development of the ShuttlePump.
Find related publications in this database (Keywords): Pistons; Blood; Pumps; Hydraulic systems; Shafts; Computational fluid dynamics; Lung; Biventricular heart failure; blood pump; computational fluid dynamics; hemocompatibility; rotary piston pump; total artificial heart