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Selected Publication:

SHR Neuro Cancer Cardio Lipid Metab Microb

Nolan, CJ; Desoye, G.
Disentangling fetal insulin hypersecretion and insulin resistance.
Trends Endocrinol Metab. 2024; Doi: 10.1016/j.tem.2024.04.008
Web of Science PubMed FullText FullText_MUG

Co-authors Med Uni Graz: Desoye Gernot
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Abstract:: Disentangling which of insulin hypersecretion and insulin resistance is upstream in obesity-related type 2 diabetes (T2D) is challenging. Here, we consider the dynamics of insulin secretion and action in the fetuses of mothers with diabetes. We argue that fetal insulin hypersecretion occurs first, with insulin resistance being an adaptive protective response.