Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Kneidinger, N; Giessen, C; von, Wulffen, W; Milger, K; Schramm, R; Jäger, G; Nitschko, H; Striebinger, H; Behr, J; Neurohr, C.
Trip to immunity: resistant cytomegalovirus infection in a lung transplant recipient.
Int J Infect Dis. 2014; 28:140-2
Doi: 10.1016/j.ijid.2014.06.009
(- Case Report)
Web of Science
PubMed
FullText
FullText_MUG
- Führende Autor*innen der Med Uni Graz
- Kneidinger Nikolaus
- Co-Autor*innen der Med Uni Graz
- Milger-Kneidinger Katrin
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- Abstract:
- We report the case of a young female lung transplant recipient with difficult-to-treat cytomegalovirus (CMV) disease. While treatment with intravenous (IV) ganciclovir failed due to antiviral drug resistance, a trial with foscarnet resulted in severe side effects. In addition, the patient received IV CMV-specific immune globulins as adjunctive therapy and leflunomide as experimental therapy. In this context, CMV-specific immune monitoring was performed and was successfully implemented in management decisions. The patient was screened for acquisition of an adaptive immune response, and antiviral prophylaxis and therapy was tailored according to results. This report highlights the impact of CMV-specific immune monitoring on individualized therapy for appropriate prophylaxis and management of CMV infection and diseases.
- Find related publications in this database (using NLM MeSH Indexing)
- Adult - administration & dosage
- Antiviral Agents - therapeutic use
- Cytomegalovirus Infections - diagnosis, drug therapy, immunology
- Drug Resistance, Viral - administration & dosage
- Female - administration & dosage
- Foscarnet - therapeutic use
- Ganciclovir - therapeutic use
- Humans - administration & dosage
- Immunoglobulins - therapeutic use
- Immunoglobulins, Intravenous - administration & dosage
- Isoxazoles - therapeutic use
- Leflunomide - administration & dosage
- Lung Transplantation - administration & dosage
- Monitoring, Immunologic - administration & dosage
- Transplant Recipients - administration & dosage
- Find related publications in this database (Keywords)
- Transplantation
- Cytomegalovirus
- Leflunomide
- Ganciclovir resistance
- Immune monitoring