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SHR Neuro Cancer Cardio Lipid Metab Microb

Niedoszytko, M; Gorska, A; Brockow, K; Bonadonna, P; Lange, M; Kluin-Nelemans, H; Oude-Elberink, H; Sabato, V; Shoumariyeh, K; von, Bubnoff, D; Müller, S; Illerhaus, A; Doubek, M; Angelova-Fischer, I; Hermine, O; Arock, M; Elena, C; Malcovati, L; Yavuz, AS; Schug, TD; Fortina, AB; Judit, V; Gotlib, J; Panse, J; Vucinic, V; Reiter, A; Schwaab, J; Triggiani, M; Mattsson, M; Breynaert, C; Romantowski, J; Zanotti, R; Olivieri, E; Zink, A; van, de, Ven, A; Stefan, A; Barete, S; Caroppo, F; Perkins, C; Kennedy, V; Christen, D; Jawhar, M; Luebke, J; Parente, R; Levedahl, K; Hadzijusufovic, E; Hartmann, K; Nedoszytko, B; Sperr, WR; Valent, P.
Prevalence of hypersensitivity reactions in various forms of mastocytosis: A pilot study of 2485 adult patients with mastocytosis collected in the ECNM registry.
Allergy. 2024; Doi: 10.1111/all.16132
Web of Science PubMed FullText FullText_MUG

Co-authors Med Uni Graz: Schug Tanja Daniela
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Abstract:: BACKGROUND: Hypersensitivity reactions (HR) are common in mastocytosis. However, little is known about triggers and risk factors. The registry of the European Competence Network on Mastocytosis (ECNM) enables reliable studies in a larger cohort of mastocytosis patients. We assessed prevalence, triggers and risk factors of HR in adults with mastocytosis in the ECNM registry. METHODS: Data were collected in 27 ECNM centers. We analyzed potential triggers (Hymenoptera venoms, food, drug, inhalant and others) and risk factors at diagnosis and during follow-up. The study group consisted of 2485 adults with mastocytosis, 1379 women (55.5%) and 1106 men (44.5%). Median age was 48.2 years (range 18-91 years). RESULTS: Nine hundred and forty eight patients (38.1%) reported one or more HR`. Most common triggers were Hymenoptera venoms in cutaneous mastocytosis (CM) and indolent systemic mastocytosis (ISM), whereas in advanced SM (advSM), most common elicitors were drugs, including nonsteroidal anti-inflammatory agents and penicillin. In multivariate analyses, tryptase level < 90 ng/mL, <15% infiltration by mast cells in bone marrow biopsy-sections, and diagnosis of ISM were identified as independent risk factors for HR. For drug-induced HR, prominent risk factors were advSM and high tryptase levels. New reactions were observed in 4.8% of all patients during 4 years follow-up. CONCLUSIONS: HR are mainly triggered by Hymenoptera venoms in patients with CM and ISM and by drugs in patients with advSM. Tryptase levels <90 ng/mL, mast cell bone marrow infiltration <15%, and WHO category ISM are predictors of HR. New HR occur in 4.8% of all patients within 4 years.
Find related publications in this database (Keywords): allergy; drug hypersensitivity; food hypersensitivity; hymenoptera venoms; immunohistochemistry; mastocytosis; tryptase