Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Kiss, C; Wurth, S; Heschl, B; Khalil, M; Gattringer, T; Enzinger, C; Ropele, S.
Low-frequency MR elastography reveals altered deep gray matter viscoelasticity in multiple sclerosis.
Neuroimage Clin. 2024; 42: 103606
Doi: 10.1016/j.nicl.2024.103606
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- Führende Autor*innen der Med Uni Graz
- Kiss Christian
- Co-Autor*innen der Med Uni Graz
- Enzinger Christian
- Gattringer Thomas
- Khalil Michael
- Ropele Stefan
- Wurth Sebastian
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- Abstract:
- INTRODUCTION: Brain viscoelasticity as assessed by magnetic resonance elastography (MRE) has been discussed as a promising surrogate of microstructural alterations due to neurodegenerative processes. Existing studies indicate that multiple sclerosis (MS) is associated with a global reduction in brain stiffness. However, no study to date systematically investigated the MS-related characteristics of brain viscoelasticity separately in normal-appearing white matter (NAWM), deep gray matter (DGM) and T2-hyperintense white matter (WM) lesions. METHODS: 70 MS patients and 42 healthy volunteers underwent whole-cerebral MRE using a stimulated echo sequence (DENSE) with a low-frequency mechanical excitation at 20 Hertz. The magnitude |G∗| (Pa) and phase angle φ (rad) of the complex shear modulus G∗ were reconstructed by multifrequency dual elasto-visco (MDEV) inversion and related to structural imaging and clinical parameters. RESULTS: We observed φ in the thalamus to be higher by 4.3 % in patients relative to healthy controls (1.11 ± 0.07 vs. 1.06 ± 0.07, p < 0.0001). Higher Expanded Disability Status Scale (EDSS) scores were negatively associated with φ in the basal ganglia (p = 0.01). We measured φ to be lower in MS lesions compared to surrounding NAWM (p = 0.001), which was most prominent for lesions in the temporal lobe (1.01 ± 0.22 vs. 1.06 ± 0.19, p = 0.003). Age was associated with lower values of |G∗| (p = 0.04) and φ (p = 0.004) in the thalamus of patients. No alteration in NAWM stiffness relative to WM in healthy controls was observed. CONCLUSION: Low-frequency elastography in MS patients reveals age-independent alterations in the viscoelasticity of deep gray matter at early stages of disease.
- Find related publications in this database (using NLM MeSH Indexing)
- Humans - administration & dosage
- Elasticity Imaging Techniques - methods
- Female - administration & dosage
- Male - administration & dosage
- Gray Matter - diagnostic imaging, pathology
- Adult - administration & dosage
- Middle Aged - administration & dosage
- Multiple Sclerosis - diagnostic imaging, pathology, physiopathology
- Magnetic Resonance Imaging - methods
- White Matter - diagnostic imaging, pathology
- Young Adult - administration & dosage
- Find related publications in this database (Keywords)
- Magnetic resonance elastography
- Multiple sclerosis
- Viscoelasticity
- Stiffness
- Brain
- Deep Gray Matter