Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Pinter, K; Rosenkranz, A.
Cholemic Nephropathy: Role in Acute Kidney Injury in Cholestasis and Cirrhosis.
Adv Kidney Dis Health. 2024; 31(2):111-126
Doi: 10.1053/j.akdh.2023.07.001
Web of Science
PubMed
FullText
FullText_MUG
- Führende Autor*innen der Med Uni Graz
- Pinter Klemens
- Rosenkranz Alexander
- Altmetrics:
- Dimensions Citations:
- Plum Analytics:
- Scite (citation analytics):
- Abstract:
- The concept of structural kidney damage and renal dysfunction as a result of jaundice attracted attention in the medical community in the early and mid-20th century. The postulated doctrine of the time was that the excretion of elevated concentrations of bile results in bile-stained casts occupying collecting and distal convoluted tubules, degeneration of tubular epithelium, and decreased renal function. Compared to the hepatorenal syndrome, the poster child of hepatology and nephrology collaboration, the notion of structural kidney damage and renal dysfunction as a result of cholemia lost its traction and has almost disappeared from modern textbooks. Today, cholemic nephropathy is experiencing a renaissance, with multiple case reports and case series of jaundiced patients with kidney dysfunction and evidence of bile acid casts upon histologic examination. Published cases include acute hepatitis, chronic liver injury, cirrhosis, and obstructive etiologies. Diagnosis of cholemic nephropathy is based on histological examination, typically showing intraluminal bile casts predominantly located in the distal tubules. In common bile duct-ligated mice, the histomorphological and functional alterations of cholemic nephropathy mimic those seen in humans. Some argue against the concept of cholemic nephropathy and postulate that bile casts are a secondary phenomenon. What we need are carefully designed trials to establish diagnostic criteria and subsequently translate this knowledge into evidence-based therapies.
- Find related publications in this database (using NLM MeSH Indexing)
- Humans - administration & dosage
- Acute Kidney Injury - pathology, etiology
- Cholestasis - pathology, complications
- Liver Cirrhosis - complications, pathology
- Animals - administration & dosage
- Bile Acids and Salts - metabolism
- Find related publications in this database (Keywords)
- Cholemic nephropathy
- Acute kidney injury
- Hepatorenal syndrome
- Bile cast nephropathy
- Liver cirrhosis
- Jaundice-related nephropathy
- Bile acid nephropathy