Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
de Jager, VD; Timens, W; Bayle, A; Botling, J; Brcic, L; Buettner, R; Fernandes, MGO; Havel, L; Hochmair, M; Hofman, P; Janssens, A; van Kempe, L; Kern, I; Machado, JC; Mohorcic, K; Popat, S; Ryska, A; Wolf, J; Schuuring, E; van der Wekken, AJ.
Future perspective for the application of predictive biomarkertesting in advanced stage non-small cell lung cance
LANCET REG HEALTH-EU. 2024; 38: 100840
Doi: 10.1016/j.lanepe.2024.100840
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- Abstract:
- For patients with advanced stage non-small cell lung cancer (NSCLC), treatment strategies have changed significantly due to the introduction of targeted therapies and immunotherapy. In the last few years, we have seen an explosive growth of newly introduced targeted therapies in oncology and this development is expected to continue in the future. Besides primary targetable aberrations, emerging diagnostic biomarkers also include relevant co-occurring mutations and resistance mechanisms involved in disease progression, that have impact on optimal treatment management. To accommodate testing of pending biomarkers, it is necessary to establish routine large-panel next-generation sequencing (NGS) for all patients with advanced stage NSCLC. For cost-effectiveness and accessibility, it is recommended to implement predictive molecular testing using large-panel NGS in a dedicated, centralized expert laboratory within a regional oncology network. The central molecular testing center should host a regional Molecular Tumor Board and function as a hub for interpretation of rare and complex testing results and clinical decision-making.
- Find related publications in this database (Keywords)
- Predictive biomarker testing
- Next-generation sequencing
- Non-small cell lung cancer