Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Smolle, MA; Reinbacher, P; Sadoghi, P.
Trial of Vancomycin and Cefazolin as Surgical Prophylaxis
NEW ENGL J MED. 2024; 390(5): 480-482.
Doi: 10.1056/NEJMc2313673
Web of Science
PubMed
FullText
FullText_MUG
- Führende Autor*innen der Med Uni Graz
- Smolle Maria Anna
- Co-Autor*innen der Med Uni Graz
- Reinbacher Patrick
- Sadoghi Patrick
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- Abstract:
- To the Editor: In their multicenter, phase 4, randomized, controlled trial, Peel et al. (Oct. 19 issue)(1) showed that preoperative vancomycin provided no additive benefit as compared with cefazolin prophylaxis alone for the prevention of surgical-site infection within 90 days after total joint arthroplasty. We want to underline the fact that more than 75% of the trial participants underwent preoperative screening for methicillin-resistant Staphylococcus aureus (MRSA), and those with known MRSA colonization were primarily excluded. This characteristic of the trial potentially impairs the generalizability of the findings, because MRSA screening and decolonization protocols vary substantially among countries.(2,3) Therefore, despite the . . .