Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Burgstaller, S; Bischof, H; Matt, L; Lukowski, R.
Assessing K+ ions and K+ channel functions in cancer cell metabolism using fluorescent biosensors.
Free Radic Biol Med. 2022; 181: 43-51.
Doi: 10.1016/j.freeradbiomed.2022.01.026
Web of Science
PubMed
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FullText_MUG
- Führende Autor*innen der Med Uni Graz
- Burgstaller Sandra
- Co-Autor*innen der Med Uni Graz
- Bischof Helmut
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- Abstract:
- Cancer represents a leading cause of death worldwide. Hence, a better understanding of the molecular mechanisms causing and propelling the disease is of utmost importance. Several cancer entities are associated with altered K+ channel expression which is frequently decisive for malignancy and disease outcome. The impact of such oncogenic K+ channels on cell patho-/physiology and homeostasis and their roles in different subcellular compartments is, however, far from being understood. A refined method to simultaneously investigate metabolic and ionic signaling events on the level of individual cells and their organelles represent genetically encoded fluorescent biosensors, that allow a high-resolution investigation of compartmentalized metabolite or ion dynamics in a non-invasive manner. This feature of these probes makes them versatile tools to visualize and understand subcellular consequences of aberrant K+ channel expression and activity in K+ channel related cancer research.
- Find related publications in this database (using NLM MeSH Indexing)
- Biosensing Techniques - administration & dosage
- Fluorescence Resonance Energy Transfer - administration & dosage
- Fluorescent Dyes - administration & dosage
- Humans - administration & dosage
- Ions - administration & dosage
- Neoplasms - genetics
- Find related publications in this database (Keywords)
- Cancer
- Potassium ions
- K
- Potassium ion channels
- Biosensors
- FRET
- Fluorescence
- Live-cell imaging
- Microscopy
- Metabolism