Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Aberger, S; Kolland, M; Eller, K; Rosenkranz, AR; Kirsch, AH.
Differences in drug removal between standard high-flux and medium cut-off dialyzers in a case of severe vancomycin toxicity.
CLIN KIDNEY J. 2024; 17(4): sfae063
Doi: 10.1093/ckj/sfae063
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- Führende Autor*innen der Med Uni Graz
- Aberger Simon Michael
- Kirsch Alexander
- Co-Autor*innen der Med Uni Graz
- Eller Kathrin
- Kolland Michael
- Rosenkranz Alexander
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- Abstract:
- Vancomycin is a widely used glycopeptide antibiotic with the need for therapeutic drug monitoring to avoid renal toxicity. We report a case of severe vancomycin-associated anuric acute kidney injury managed with successful drug-removal by hemodialysis (HD) using different types of dialyzers. Medium cut-off (MCO) and high-flux dialyzers were effective in drug removal. Higher vancomycin elimination rate and lower plasma half-life were achieved with MCO dialyzer despite low-flow vascular access and intolerance to ultrafiltration. MCO dialyzers may be reasonable for drug removal in patients with intolerance of ultrafiltration, low-flow vascular access or impracticality of hemodiafiltration. Future studies should explore the use of MCO dialyzers in comparison with high-flux HD and hemodiafiltration in both the acute and chronic setting.
- Find related publications in this database (Keywords)
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