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SHR Neuro Cancer Cardio Lipid Metab Microb

Dusleag, M; Urlesberger, B; Schwaberger, B; Baik-Schneditz, N; Schlatzer, C; Wolfsberger, CH; Pichler, G.
Acid base and metabolic parameters of the umbilical cord blood and cerebral oxygenation immediately after birth.
Front Pediatr. 2024; 12: 1385726 Doi: 10.3389/fped.2024.1385726 [OPEN ACCESS]
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Leading authors Med Uni Graz: Pichler Gerhard
Co-authors Med Uni Graz: Baik-Schneditz Nariae; Schlatzer Christoph; Schwaberger Bernhard; Urlesberger Berndt; Wolfsberger Christina Helene
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Abstract:: OBJECTIVE: Aim was to investigate whether acid-base and metabolic parameters obtained from arterial umbilical cord blood affect cerebral oxygenation after birth in preterm neonates with respiratory support and in term neonates without respiratory support. STUDY DESIGN: This was a post-hoc analysis of secondary outcome parameters of a prospective observational study including preterm neonates with and term neonates without respiratory support. Non-asphyxiated neonates with cerebral oxygenation measured with near-infrared spectroscopy during the first 15 min and with blood gas analyses from arterial umbilical cord blood were included. Arterial oxygen saturation (SpO₂) and heart rate (HR) were monitored with pulse oximetry. Potential correlations were investigated between acid-base and metabolic parameters (pH-value, bicarbonate, base-excess, and lactate) and crSO₂/cFTOE 5 min after birth. RESULTS: Seventy-seven neonates were included: 14 preterm neonates with respiratory support (mean gestational age [GA] 31.4 ± 4.1 weeks; mean birth weight [BW] 1,690 ± 640 g) and 63 term neonates without respiratory support (GA 38.7 ± 0.8 weeks; BW 3,258 ± 443 g). Mean crSO₂ 5 min after birth was 44.0% ± 24.2% in preterm and 62.2% ± 20.01% in term neonates. Mean cFTOE 5 min after birth was 0.46 ± 0.06 in preterm and 0.27 ± 0.19 in term neonates. In preterm neonates with respiratory support higher lactate was significantly associated with lower crSO₂ and SpO₂ and tended to be associated with higher cFTOE. In term neonates without respiratory support no significant correlations were found. CONCLUSION: In non-asphyxiated preterm neonates with respiratory support, lactate levels were negatively associated with crSO₂ and SpO₂, whereas in term neonates without respiratory support no associations were observed.
Find related publications in this database (Keywords): neonates; acid-base and metabolic parameters; cerebral oxygenation; immediate neonatal transition; near-infrared spectroscopy