Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Volkenandt, M; Cerroni, L; Rieger, E; Soyer, HP; Koch, O; Wienecke, R; Atzpodien, J; Bertino, JR; Kerl, H.
Analysis of the 14;18 translocation in cutaneous lymphomas using the polymerase chain reaction.
J Cutan Pathol. 1992; 19(5):353-356
Doi: 10.1111/j.1600-0560.1992.tb00605.x
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- Co-Autor*innen der Med Uni Graz
- Cerroni Lorenzo
- Kerl Helmut
- Soyer Hans Peter
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- Abstract:
- A series of 25 cutaneous B-cell lymphoid proliferations was analyzed for the presence of the (14; 18) translocation using the polymerase chain reaction. Junctional sequences of rearranged chromosomes 14 and 18 were amplified in vitro, and t (14; 18) specific sequences were detected in 1 of 14 primary cutaneous B-cell lymphomas, in 3 of 8 primary nodal B-cell lymphomas and in none of 3 B-cell pseudolymphomas. These results indicate that the t (14; 18) may occur in a small subset of primary cutaneous lymphoma. However, the difference in incidence of the t (14; 18) between primary nodal and primary cutaneous lymphomas suggests that different molecular mechanisms are involved in the pathogenesis of these lymphomas.
- Find related publications in this database (using NLM MeSH Indexing)
- Base Sequence -
- Chromosomes, Human, Pair 14 -
- Chromosomes, Human, Pair 18 -
- DNA, Neoplasm - genetics
- Gene Amplification -
- Humans -
- Immunohistochemistry -
- Lymphoma, B-Cell - genetics
- Molecular Sequence Data -
- Polymerase Chain Reaction -
- Skin Neoplasms - genetics
- Translocation, Genetic -