Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Danne, TPA; Joubert, M; Hartvig, NV; Kaas, A; Knudsen, NN; Mader, JK.
Association Between Treatment Adherence and Continuous Glucose Monitoring Outcomes in People With Diabetes Using Smart Insulin Pens in a Real-World Setting.
Diabetes Care. 2024; 47(6):995-1003
Doi: 10.2337/dc23-2176
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- Co-Autor*innen der Med Uni Graz
- Mader Julia
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- Abstract:
- OBJECTIVE: To evaluate the association of insulin injection adherence, smart insulin pen engagement, and glycemic control using real-world data from 16 countries from adults self-administering basal insulin degludec and bolus insulin with a smart insulin pen (NovoPen 6 or NovoPen Echo Plus) alongside continuous glucose monitoring (CGM). RESEARCH DESIGN AND METHODS: Data were aggregated over 14-day periods. Treatment adherence was defined according to the number of missed basal and missed bolus insulin doses and smart pen engagement according to the number of days with data uploads. RESULTS: Data from 3,945 adults, including 25,157 14-day periods with ≥70% CGM coverage, were analyzed. On average, 0.2 basal and 6.0 bolus insulin doses were missed over 14 days. The estimated probability of missing at least one basal insulin dose over a 14-day period was 17.6% (95% CI 16.5, 18.7). Missing one basal or bolus insulin dose per 14 days was associated with a significant decrease in percentage of time with glucose levels in range (TIR) (3.9-10.0 mmol/L), of -2.8% (95% CI -3.7, -1.8) and -1.7% (-1.8, -1.6), respectively; therefore, missing two basal or four bolus doses would decrease TIR by >5%. Smart pen engagement was associated positively with glycemic outcomes. CONCLUSIONS: This combined analysis of real-world smart pen and CGM data showed that missing two basal or four bolus insulin doses over a 14-day period would be associated with a clinically relevant decrease in TIR. Smart insulin pens provide valuable insights into treatment injection behaviors.
- Find related publications in this database (using NLM MeSH Indexing)
- Humans - administration & dosage
- Male - administration & dosage
- Female - administration & dosage
- Middle Aged - administration & dosage
- Insulin - administration & dosage, therapeutic use
- Blood Glucose Self-Monitoring - instrumentation
- Blood Glucose - analysis, drug effects
- Hypoglycemic Agents - administration & dosage, therapeutic use
- Adult - administration & dosage
- Aged - administration & dosage
- Treatment Adherence and Compliance - statistics & numerical data
- Insulin, Long-Acting - administration & dosage, therapeutic use
- Diabetes Mellitus - drug therapy, blood
- Diabetes Mellitus, Type 1 - drug therapy, blood
- Continuous Glucose Monitoring - administration & dosage