Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Bacsa, B; Hopl, V; Derler, I.
Synthetic Biology Meets Ca2+ Release-Activated Ca2+ Channel-Dependent Immunomodulation.
Cells. 2024; 13(6): 468
Doi: 10.3390/cells13060468
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- Führende Autor*innen der Med Uni Graz
- Bacsa Bernadett
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- Abstract:
- Many essential biological processes are triggered by the proximity of molecules. Meanwhile, diverse approaches in synthetic biology, such as new biological parts or engineered cells, have opened up avenues to precisely control the proximity of molecules and eventually downstream signaling processes. This also applies to a main Ca2+ entry pathway into the cell, the so-called Ca2+ release-activated Ca2+ (CRAC) channel. CRAC channels are among other channels are essential in the immune response and are activated by receptor-ligand binding at the cell membrane. The latter initiates a signaling cascade within the cell, which finally triggers the coupling of the two key molecular components of the CRAC channel, namely the stromal interaction molecule, STIM, in the ER membrane and the plasma membrane Ca2+ ion channel, Orai. Ca2+ entry, established via STIM/Orai coupling, is essential for various immune cell functions, including cytokine release, proliferation, and cytotoxicity. In this review, we summarize the tools of synthetic biology that have been used so far to achieve precise control over the CRAC channel pathway and thus over downstream signaling events related to the immune response.
- Find related publications in this database (using NLM MeSH Indexing)
- Calcium Signaling - physiology
- Synthetic Biology - administration & dosage
- Stromal Interaction Molecule 1 - metabolism
- Calcium Release Activated Calcium Channels - metabolism
- Immunity - administration & dosage
- Find related publications in this database (Keywords)
- CRAC channels
- STIM1
- Orai1
- calcium (Ca2+) synthetic biology
- chemical inducers of dimerization
- proteolytic cleavage
- optogenetics
- engineered immune cells