Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Trummer, O; Hoeller, J; Reintar, S; Tandl, V; Foessl, I; Borzan, V; Theiler-Schwetz, V; Trummer, C; Lerchbaum, E; Obermayer-Pietsch, B.
Serum Expression of miR-23a-3p and miR-424-5p Indicate Specific Polycystic Ovary Syndrome Phenotypes: A Pilot Study.
Int J Mol Sci. 2024; 25(6):
Doi: 10.3390/ijms25063205
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- Führende Autor*innen der Med Uni Graz
- Trummer Olivia
- Co-Autor*innen der Med Uni Graz
- Borzan Valentin
- Fößl Ines
- Höller Jonas
- Lerchbaum Elisabeth
- Obermayer-Pietsch Barbara
- Reintar Sharmaine
- Tandl Veronika
- Theiler-Schwetz Verena
- Trummer Christian
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- Abstract:
- MicroRNAs (miRNAs) are single-stranded, non-coding RNAs that regulate mRNA expression on a post-transcriptional level. Observational studies suggest an association of serum miRNAs and polycystic ovary syndrome (PCOS), a common heterogeneous endocrinopathy characterized by hyperandrogenism (HA), oligo- or amenorrhea (OM) and polycystic ovaries. It is not known whether these miRNA profiles also differ between PCOS phenotypes. In this pilot study, we compared serum expression profiles between the four PCOS phenotypes (A-D) and analyzed them both in PCOS (all phenotypes) and in phenotypes with HA by quantitative-real-time PCR (qRT-PCR). The serum expression of miR-23a-3p was upregulated in phenotype B (n = 10) and discriminated it from phenotypes A (n = 11), C (n = 11) and D (n = 11, AUC = 0.837; 95%CI, 0.706-0.968; p = 0.006). The expression of miR-424-5p was downregulated in phenotype C (n = 11) and discriminated it from phenotypes A, B and D (AUC = 0.801; 95%CI, 0.591-1.000; p = 0.007). MiR-93-5p expression was downregulated in women with PCOS (all phenotypes, n = 42) compared to controls (n = 8; p = 0.042). Phenotypes with HA (A, B, C; n = 32) did not show differences in the analyzed expression pattern. Our data provide new insights into phenotype-specific miRNA alterations in the serum of women with PCOS. Understanding the differential hormonal and miRNA profiles across PCOS phenotypes is important to improve the pathophysiological understanding of PCOS heterogeneity.
- Find related publications in this database (using NLM MeSH Indexing)
- Humans - administration & dosage
- Female - administration & dosage
- Polycystic Ovary Syndrome - metabolism
- Pilot Projects - administration & dosage
- Hyperandrogenism - genetics
- MicroRNAs - genetics, metabolism
- Phenotype - administration & dosage
- Find related publications in this database (Keywords)
- miRNA
- polycystic ovary syndrome
- PCOS phenotypes
- Rotterdam criteria
- hyperandrogenism