Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Trauner, M; Halilbasic, E; Tatscher, E; Fickert, P.
[Primary sclerosing cholangitis-Diagnosis and treatment 2024].
INNERE MED. 2024; 65(4): 347-356.
Doi: 10.1007/s00108-024-01697-0
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- Führende Autor*innen der Med Uni Graz
- Fickert Peter
- Trauner Michael
- Co-Autor*innen der Med Uni Graz
- Halilbasic Emina
- Tatscher Elisabeth
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- Abstract:
- The etiology of primary sclerosing cholangitis (PSC) remains unclear, which explains in part the lack of a causal treatment. The differential diagnostic distinction from the even rarer immunoglobulin 4 (IgG4)-associated cholangitis (IAC) is becoming increasingly more successful. Advances in the understanding of different clinical courses, improvements in noninvasive diagnostics through modern magnetic resonance imaging (MRI) and the introduction of liver elastography have led to the development of improved prognostic models. The evidence for recommendations on medicinal (e.g., ursodeoxycholic acid) or endoscopic treatment (e.g., balloon dilatation and/or stent insertion) for PSC is still low. In contrast, the long-term results of liver transplantation in PSC patients are constantly improving. Due to the lack of highly sensitive and specific screening methods the early recognition of cholangiocellular carcinoma (CCC) as the most important complication is rarely successful. The continuous improvement of endoscopic retrograde cholangiopancreatography (ERCP) and direct cholangioscopy in combination with molecular biological and fluorescence in situ hybridization (FISH) analyses of bile duct tissue samples are promising for refined diagnostics. Due to the significantly increased risk of colorectal cancer, an annual colonoscopy is recommended in the presence of inflammatory bowel disease. Improvement of the early diagnostics of PSC and successful testing of new treatment strategies raise hope for a continuous improvement in the medical support of these complex patients.
- Find related publications in this database (using NLM MeSH Indexing)
- Humans - administration & dosage
- Cholangitis, Sclerosing - diagnosis
- In Situ Hybridization, Fluorescence - administration & dosage
- Liver - pathology
- Bile Ducts, Intrahepatic - pathology
- Bile Duct Neoplasms - diagnosis
- Find related publications in this database (Keywords)
- Cholestasis
- Chronic inflammatory bowel disease
- Cholangiocellular carcinoma
- Endoscopic retrograde cholangiopancreatography
- Ursodeoxycholic acid