Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Martine-Edith, G; Zaremba, N; Divilly, P; Søholm, U; Broadley, M; Baumann, PM; Mahmoudi, Z; Gomes, M; Ali, N; Abbink, EJ; de, Galan, B; Brøsen, J; Pedersen-Bjergaard, U; Vaag, AA; McCrimmon, RJ; Renard, E; Heller, S; Evans, M; Cigler, M; Mader, JK; Amiel, SA; Speight, J; Pouwer, F; Choudhary, P.
Associations Between Hypoglycemia Awareness Status and Symptoms of Hypoglycemia Among Adults with Type 1 or Insulin-Treated Type 2 Diabetes Using the Hypo-METRICS Smartphone Application.
Diabetes Technol Ther. 2024; 26(8):566-574
Doi: 10.1089/dia.2023.0596
Web of Science
PubMed
FullText
FullText_MUG
- Co-Autor*innen der Med Uni Graz
- Baumann Petra Martina
- Cigler Monika
- Mader Julia
- Altmetrics:
- Dimensions Citations:
- Plum Analytics:
- Scite (citation analytics):
- Abstract:
- Introduction: This study examined associations between hypoglycemia awareness status and hypoglycemia symptoms reported in real-time using the novel Hypoglycaemia-MEasurement, ThResholds and ImpaCtS (Hypo-METRICS) smartphone application (app) among adults with insulin-treated type 1 (T1D) or type 2 diabetes (T2D). Methods: Adults who experienced at least one hypoglycemic episode in the previous 3 months were recruited to the Hypo-METRICS study. They prospectively reported hypoglycemia episodes using the app for 10 weeks. Any of eight hypoglycemia symptoms were considered present if intensity was rated between "A little bit" to "Very much" and absent if rated "Not at all." Associations between hypoglycemia awareness (as defined by Gold score) and hypoglycemia symptoms were modeled using mixed-effects binary logistic regression, adjusting for glucose monitoring method and diabetes duration. Results: Of 531 participants (48% T1D, 52% T2D), 45% were women, 91% white, and 59% used Flash or continuous glucose monitoring. Impaired awareness of hypoglycemia (IAH) was associated with lower odds of reporting autonomic symptoms than normal awareness of hypoglycemia (NAH) (T1D odds ratio [OR] 0.43 [95% confidence interval {CI} 0.25-0.73], P = 0.002); T2D OR 0.51 [95% CI 0.26-0.99], P = 0.048), with no differences in neuroglycopenic symptoms. In T1D, relative to NAH, IAH was associated with higher odds of reporting autonomic symptoms at a glucose concentration <54 than >70 mg/dL (OR 2.18 [95% CI 1.21-3.94], P = 0.010). Conclusion: The Hypo-METRICS app is sensitive to differences in hypoglycemia symptoms according to hypoglycemia awareness in both diabetes types. Given its high ecological validity and low recall bias, the app may be a useful tool in research and clinical settings. The clinical trial registration number is NCT04304963.
- Find related publications in this database (using NLM MeSH Indexing)
- Humans - administration & dosage
- Hypoglycemia - chemically induced
- Female - administration & dosage
- Diabetes Mellitus, Type 2 - drug therapy, complications, blood
- Male - administration & dosage
- Middle Aged - administration & dosage
- Diabetes Mellitus, Type 1 - drug therapy, complications, blood
- Smartphone - administration & dosage
- Insulin - therapeutic use, administration & dosage, adverse effects
- Hypoglycemic Agents - therapeutic use, adverse effects
- Adult - administration & dosage
- Mobile Applications - administration & dosage
- Blood Glucose Self-Monitoring - administration & dosage
- Awareness - administration & dosage
- Blood Glucose - analysis
- Aged - administration & dosage
- Prospective Studies - administration & dosage
- Find related publications in this database (Keywords)
- Hypo-METRICS
- Hypoglycemia symptoms
- Hypoglycemia awareness