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Selected Publication:

SHR Neuro Cancer Cardio Lipid Metab Microb

Humer, C; Schindl, R; Sallinger, M.
Crosstalk between TPC2 and IP₃R regulates Ca²⁺ signals.
Trends Cell Biol. 2024; Doi: 10.1016/j.tcb.2024.03.001
Web of Science PubMed FullText FullText_MUG

 

Leading authors Med Uni Graz

Schindl Rainer

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Abstract:

Calcium (Ca²⁺) plays a pivotal role in cellular signal transmission by triggering downstream signaling in response to an increase in the cytosolic Ca²⁺ concentration. Intracellular organelles serve as Ca²⁺ stores that induce differently shaped Ca²⁺ signals. We discuss a study by Yuan et al. that investigated the interplay between the lysosomal two-pore channel 2 (TPC2) and endoplasmic reticulum (ER)-localized inositol 1,4,5-trisphosphate receptors (IP₃Rs).

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