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SHR Neuro Cancer Cardio Lipid Metab Microb
Haizinger, B; Gombotz, H; Rehak, P; Geiselseder, G; Mair, R.
Activated thrombelastogram in neonates and infants with complex congenital heart disease in comparison with healthy children.
Br J Anaesth. 2006; 97(4):545-552
Doi: 10.1093/bja/ael206
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- Co-authors Med Uni Graz
- Rehak Peter
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- Abstract:
- Background. The goal of the study was to determine activated thrombelastographic (TEG (R)) parameters with the rotational TEG (R) (ROTEG or ROTEM) device (Pentapharm GmbH, Munich, Germany) in neonates and infants < 1 yr with complex congenital heart disease (CCHD) and to compare them with those of healthy children. Methods. A total of 59 children were included: Group I (Gr I) 24 children, ASA I, scheduled for minor surgery; and Group II (Gr II) 35 children with CCHD, ASA III-IV, scheduled for cardiac surgery. Each group was subdivided into four age groups. Blood samples were obtained before the surgical procedure. Results. Statistically significant differences (two-way anova analysis) between Gr I and Gr II [mean (sd); P-value] were found in INTEG-CT [Gr I 175(19), Gr II 271(162); P=0.049], EXTEG-MCF [Gr I 63(8), Gr II 56(8); P=0.013], EXTEG-MCE [Gr I 186(65), Gr II 137(41); P=0.003], FIBTEG-MCF [Gr I 24(7), Gr II 19(5); P=0.012], FIBTEG-MCE [Gr I 32(13), Gr II 24(8); P=0.012] and EXTEG-MCE-FIBTEG-MCE [Gr I 155(55), Gr II 113(37); P=0.003]. Clotting time via contact activation was prolonged in Gr II and varied widely, mainly in the age group 0-1 month and to a lesser extent in 1-3 months, and maximum clot firmness was reduced in the same age groups. In comparison with Gr II, the healthy children showed relatively homogenous TEG values with a tendency to hypercoagulability; the maximum was found in age group 1-3 months, decreasing towards adult values in the course of the first year of life. Conclusions. These preliminary TEG results indicate that the coagulation-fibrinolytic system in CCHD patients < 1 yr is functionally intact and balanced but at a lower level than in healthy children. This could be interpreted as a reduction in the haemostatic potential with less reserve.
- Find related publications in this database (using NLM MeSH Indexing)
- Aging - blood
- Blood Coagulation -
- Female -
- Fibrinolysis -
- Heart Defects, Congenital - blood Heart Defects, Congenital - surgery
- Humans -
- Infant -
- Infant, Newborn -
- Male -
- Preoperative Care - methods
- Prospective Studies -
- Thrombelastography -
- Find related publications in this database (Keywords)
- anaesthesia
- paediatric
- blood
- coagulation
- infants
- measurement techniques
- Thrombelastograph (R)
- neonates