Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Barletta, F; Tappero, S; Morra, S; Incesu, RB; Cano, Garcia, C; Piccinelli, ML; Scheipner, L; Tian, Z; Gandaglia, G; Stabile, A; Mazzone, E; Terrone, C; Longo, N; Tilki, D; Chun, FKH; de, Cobelli, O; Ahyai, S; Saad, F; Shariat, SF; Montorsi, F; Briganti, A; Karakiewicz, PI.
Identifying low cancer-specific mortality risk lymph node-positive radical prostatectomy patients.
J Surg Oncol. 2024; 129(7):1305-1310
Doi: 10.1002/jso.27612
Web of Science
PubMed
FullText
FullText_MUG
- Co-Autor*innen der Med Uni Graz
- Ahyai Sascha
- Scheipner Lukas
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- Abstract:
- OBJECTIVES: To identify low cancer-specific mortality (CSM) risk lymph node-positive (pN1) radical prostatectomy (RP) patients. METHODS: Within Surveillance, Epidemiology and End Results database (2010-2015) pN1 RP patients were identified. Kaplan-Meier plots and multivariable Cox-regression (MCR) models were used. Pathological characteristics were used to identify patients at lowest CSM risk. RESULTS: Overall, 2197 pN1 RP patients were identified. Overall, 5-year cancer-specific survival (CSS) rate was 93.3%. In MCR models ISUP GG1-2 (hazard ratio [HR]: 0.12, p < 0.001), GG3 (HR: 0.14, p < 0.001), GG4 (HR: 0.35, p = 0.002), pT2 (HR: 0.27, p = 0.012), pT3a (HR: 0.28, p = 0.003), pT3b (HR: 0.39, p = 0.009), and 1-2 positive lymph nodes (HR: 0.64, p = 0.04) independently predicted lower CSM. Pathological characteristics subgroups with the most protective hazard ratios were used to identify low-risk (ISUP GG1-3 and pT2-3a and 1-2 positive lymph nodes) patients versus others (ISUP GG4-5 or pT3b-4 or ≥3 positive lymph nodes). In Kaplan-Meier analyses, 5-year CSS rates were 99.3% for low-risk (n = 480, 21.8%) versus 91.8% (p < 0.001) for others (n = 1717, 78.2%). CONCLUSIONS: Lymph node-positive RP patients exhibit variable CSS rates. Within this heterogeneous group, those at very low risk of CSM may be identified based on pathological characteristics, namely ISUP GG1-3, pT2-3a, and 1-2 positive lymph nodes. Such stratification scheme might be of value for individual patients counseling, as well as in design of clinical trials.
- Find related publications in this database (using NLM MeSH Indexing)
- Humans - administration & dosage
- Male - administration & dosage
- Prostatectomy - mortality
- Prostatic Neoplasms - pathology, surgery, mortality
- Middle Aged - administration & dosage
- Aged - administration & dosage
- SEER Program - administration & dosage
- Lymphatic Metastasis - administration & dosage
- Lymph Nodes - pathology, surgery
- Survival Rate - administration & dosage
- Kaplan-Meier Estimate - administration & dosage
- Follow-Up Studies - administration & dosage
- Lymph Node Excision - mortality
- Find related publications in this database (Keywords)
- cancer-specific survival
- lymph node metastases
- prostate cancer
- prostatectomy
- SEER program