Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Pignet, AL; Schellnegger, M; Hecker, A; Kamolz, LP; Kotzbeck, P.
Modeling Wound Chronicity In Vivo: The Translational Challenge to Capture the Complexity of Chronic Wounds.
J Invest Dermatol. 2024; 144(7): 1454-1470.
Doi: 10.1016/j.jid.2023.11.024
Web of Science
PubMed
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FullText_MUG
- Führende Autor*innen der Med Uni Graz
- Pignet Anna-Lisa
- Schellnegger Marlies
- Co-Autor*innen der Med Uni Graz
- Hecker Andrzej Stanislaw
- Kamolz Lars-Peter
- Kotzbeck Petra
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- Abstract:
- In an aging society with common lifestyle-associated health issues such as obesity and diabetes, chronic wounds pose a frequent challenge that physicians face in everyday clinical practice. Therefore, nonhealing wounds have attracted much scientific attention. Several in vitro and in vivo models have been introduced to deepen our understanding of chronic wound pathogenesis and amplify therapeutic strategies. Understanding how wounds become chronic will provide insights to reverse or avoid chronicity. Although choosing a suitable model is of utmost importance to receive valuable outcomes, an ideal in vivo model capturing the complexity of chronic wounds is still missing and remains a translational challenge. This review discusses the most relevant mammalian models for wound healing studies and provides guidance on how to implement the hallmarks of chronic wounds. It highlights the benefits and pitfalls of established models and maps out future avenues for research.
- Find related publications in this database (using NLM MeSH Indexing)
- Wound Healing - physiology
- Humans - administration & dosage
- Animals - administration & dosage
- Chronic Disease - administration & dosage
- Disease Models, Animal - administration & dosage
- Translational Research, Biomedical - administration & dosage
- Wounds and Injuries - pathology
- Skin - pathology, injuries
- Find related publications in this database (Keywords)
- Ischemia
- Wound healing
- Animal models
- Chronic wounds
- In vivo