Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
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SHR Neuro Krebs Kardio Lipid Stoffw Microb
Hechenberger, S; Helmlinger, B; Tinauer, C; Jauk, E; Ropele, S; Heschl, B; Wurth, S; Damulina, A; Eppinger, S; Demjaha, R; Khalil, M; Enzinger, C; Pinter, D.
Evaluation of a self-administered iPad®-based processing speed assessment for people with multiple sclerosis in a clinical routine setting.
J Neurol. 2024; 271(6):3268-3278
Doi: 10.1007/s00415-024-12274-8
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- Führende Autor*innen der Med Uni Graz
- Hechenberger Stefanie Maria Charlotte
- Pinter Daniela Theresia
- Co-Autor*innen der Med Uni Graz
- Damulina Anna
- Demjaha Rina
- Enzinger Christian
- Eppinger Sebastian
- Helmlinger Birgit
- Jauk Emanuel
- Khalil Michael
- Ropele Stefan
- Tinauer Christian Gerhard
- Wurth Sebastian
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- Abstract:
- BACKGROUND: Limited resources often hinder regular cognitive assessment of people with multiple sclerosis (pwMS) in standard clinical care. A self-administered iPad®-based cognitive screening-tool (Processing Speed Test; PST) might mitigate this problem. OBJECTIVE: To evaluate the PST in clinical routine. METHODS: We investigated the feasibility of the PST in both a quiet and a waiting room setting. We assessed the validity of the PST in comparison with the established Symbol Digit Modalities Test (SDMT). We explored associations between processing speed assessments and the Brief International Cognitive Assessment for MS (BICAMS), magnetic resonance imaging (MRI) parameters, and psychological factors. Additionally, we explored the ability of the PST to detect impairment in processing speed compared to the SDMT. RESULTS: The PST was feasible in the waiting room setting. PST and SDMT correlated comparably with the BICAMS, MRI parameters, and psychological variables. Of 172 pwMS, 50 (30.8%) showed cognitive impairment according to the BICAMS; respective values were 47 (27.3%) for the SDMT and 9 (5.2%) for the PST. CONCLUSIONS: The PST performed in a waiting room setting correlates strongly with established cognitive tests. It thus may be used to assess processing speed in a resource-efficient manner and complement cognitive assessment in clinical routine. Despite comparable validity of the PST and SDMT, we identified more pwMS with impaired processing speed using normative data of the SDMT compared to the PST and advise caution, that the common cut-off score of - 1.5 SD from the current PST is not appropriate in Europe.
- Find related publications in this database (using NLM MeSH Indexing)
- Humans - administration & dosage
- Multiple Sclerosis - diagnostic imaging
- Male - administration & dosage
- Female - administration & dosage
- Middle Aged - administration & dosage
- Adult - administration & dosage
- Neuropsychological Tests - administration & dosage
- Cognitive Dysfunction - etiology, diagnosis, diagnostic imaging
- Computers, Handheld - administration & dosage
- Feasibility Studies - administration & dosage
- Magnetic Resonance Imaging - administration & dosage
- Aged - administration & dosage
- Processing Speed - administration & dosage
- Find related publications in this database (Keywords)
- Multiple sclerosis
- Cognition
- Processing speed
- Cognitive assessment
- MRI
- iPad (R)-based test