Medizinische Universität Graz - Research portal

Go directly to the nagivation.
Go directly to the content.

Navigation/Search

Selected Publication:

SHR Neuro Cancer Cardio Lipid Metab Microb

Alnajar, H; Ravichandran, H; Figueiredo, Rendeiro, A; Ohara, K; Al, Zoughbi, W; Manohar, J; Greco, N; Sigouros, M; Fox, J; Muth, E; Angiuoli, S; Faltas, B; Shusterman, M; Sternberg, CN; Elemento, O; Mosquera, JM.
Tumor-immune microenvironment revealed by Imaging Mass Cytometry in a metastatic sarcomatoid urothelial carcinoma with a prolonged response to pembrolizumab.
Cold Spring Harb Mol Case Stud. 2022; 8(3): Doi: 10.1101/mcs.a006151 (- Case Report) [OPEN ACCESS]
Web of Science PubMed FullText FullText_MUG

Co-authors Med Uni Graz: Al-Zoughbi Wael
Altmetrics:
Dimensions Citations:
Plum Analytics:
Scite (citation analytics):
Abstract:: Sarcomatoid urothelial carcinoma (SUC) is a rare subtype of urothelial carcinoma (UC) that typically presents at an advanced stage compared to more common variants of UC. Locally advanced and metastatic UC have a poor long-term survival following progression on first-line platinum-based chemotherapy. Antibodies directed against the programmed cell death 1 protein (PD-1) or its ligand (PD-L1) are now approved to be used in these scenarios. The need for reliable biomarkers for treatment stratification is still under research. Here, we present a novel case report of the first Imaging Mass Cytometry (IMC) analysis done in SUC to investigate the immune cell repertoire and PD-L1 expression in a patient who presented with metastatic SUC and experienced a prolonged response to the anti-PD1 immune checkpoint inhibitor pembrolizumab after progression on first-line chemotherapy. This case report provides an important platform for translating these findings to a larger cohort of UC and UC variants.
Find related publications in this database (using NLM MeSH Indexing): Antibodies, Monoclonal, Humanized - administration & dosage; Antineoplastic Agents, Immunological - therapeutic use; B7-H1 Antigen - administration & dosage; Carcinoma, Transitional Cell - drug therapy, pathology; Female - administration & dosage; Humans - administration & dosage; Image Cytometry - administration & dosage; Male - administration & dosage; Sarcoma - drug therapy; Soft Tissue Neoplasms - administration & dosage; Tumor Microenvironment - administration & dosage; Urinary Bladder Neoplasms - drug therapy, pathology
Find related publications in this database (Keywords): neoplasm of the genitourinary tract