Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Martine-Edith, G; Divilly, P; Zaremba, N; Søholm, U; Broadley, M; Baumann, PM; Mahmoudi, Z; Gomes, M; Ali, N; Abbink, EJ; de, Galan, B; Brøsen, J; Pedersen-Bjergaard, U; Vaag, AA; McCrimmon, RJ; Renard, E; Heller, S; Evans, M; Cigler, M; Mader, JK; Speight, J; Pouwer, F; Amiel, SA; Choudhary, P; Hypo-Resolve, FT.
A Comparison of the Rates of Clock-Based Nocturnal Hypoglycemia and Hypoglycemia While Asleep Among People Living with Diabetes: Findings from the Hypo-METRICS Study.
Diabetes Technol Ther. 2024; 26(7):433-441
Doi: 10.1089/dia.2023.0522
Web of Science
PubMed
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- Co-Autor*innen der Med Uni Graz
- Baumann Petra Martina
- Cigler Monika
- Mader Julia
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- Abstract:
- Introduction: Nocturnal hypoglycemia is generally calculated between 00:00 and 06:00. However, those hours may not accurately reflect sleeping patterns and it is unknown whether this leads to bias. We therefore compared hypoglycemia rates while asleep with those of clock-based nocturnal hypoglycemia in adults with type 1 diabetes (T1D) or insulin-treated type 2 diabetes (T2D). Methods: Participants from the Hypo-METRICS study wore a blinded continuous glucose monitor and a Fitbit Charge 4 activity monitor for 10 weeks. They recorded details of episodes of hypoglycemia using a smartphone app. Sensor-detected hypoglycemia (SDH) and person-reported hypoglycemia (PRH) were categorized as nocturnal (00:00-06:00 h) versus diurnal and while asleep versus awake defined by Fitbit sleeping intervals. Paired-sample Wilcoxon tests were used to examine the differences in hypoglycemia rates. Results: A total of 574 participants [47% T1D, 45% women, 89% white, median (interquartile range) age 56 (45-66) years, and hemoglobin A1c 7.3% (6.8-8.0)] were included. Median sleep duration was 6.1 h (5.2-6.8), bedtime and waking time ∼23:30 and 07:30, respectively. There were higher median weekly rates of SDH and PRH while asleep than clock-based nocturnal SDH and PRH among people with T1D, especially for SDH <70 mg/dL (1.7 vs. 1.4, P < 0.001). Higher weekly rates of SDH while asleep than nocturnal SDH were found among people with T2D, especially for SDH <70 mg/dL (0.8 vs. 0.7, P < 0.001). Conclusion: Using 00:00 to 06:00 as a proxy for sleeping hours may underestimate hypoglycemia while asleep. Future hypoglycemia research should consider the use of sleep trackers to record sleep and reflect hypoglycemia while asleep more accurately. The trial registration number is NCT04304963.
- Find related publications in this database (using NLM MeSH Indexing)
- Aged - administration & dosage
- Female - administration & dosage
- Humans - administration & dosage
- Male - administration & dosage
- Middle Aged - administration & dosage
- Blood Glucose - analysis
- Blood Glucose Self-Monitoring - administration & dosage
- Circadian Rhythm - physiology
- Diabetes Mellitus, Type 1 - blood, complications
- Diabetes Mellitus, Type 2 - complications, blood
- Hypoglycemia - blood
- Hypoglycemic Agents - therapeutic use
- Insulin - administration & dosage, therapeutic use
- Sleep - physiology
- Find related publications in this database (Keywords)
- Hypo-METRICS
- Nocturnal hypoglycemia
- Continuous glucose monitoring
- Sleep tracking
- Fitbit