Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Tomelleri, A; Dejaco, C.
New blood biomarkers and imaging for disease stratification and monitoring of giant cell arteritis.
RMD Open. 2024; 10(1): e003397
Doi: 10.1136/rmdopen-2023-003397
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PubMed
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- Führende Autor*innen der Med Uni Graz
- Dejaco Christian
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- Abstract:
- Relapses and late complications remain a concern in giant cell arteritis (GCA). Monitoring strategies are required to effectively tailor treatment and improve patients' outcomes. Current monitoring of GCA is based on clinical assessment and evaluation of traditional inflammatory markers such as C reactive protein and erythrocyte sedimentation rate; however, this approach has limited value in patients receiving interleukin (IL)-6 blocking agents. New blood biomarkers that are less dependent on the IL-6 axis such as IL-23, B cell activating factor, osteopontin and calprotectin have been explored, but none of them has yet accumulated sufficient evidence to qualify as a routine follow-up parameter. Imaging techniques, including ultrasound and 18F-fluorodeoxyglucose positron emission tomography/computed tomography, potentially offer additional insights; however, the choice of the imaging method as well as its interpretation must be investigated further. Future studies are required to investigate the outcome of patients with GCA whose treatment decisions are based on traditional plus novel (laboratory and imaging) biomarkers as compared with those undergoing conventional monitoring strategies.
- Find related publications in this database (using NLM MeSH Indexing)
- Humans - administration & dosage
- Giant Cell Arteritis - diagnostic imaging, complications
- Diagnostic Imaging - administration & dosage
- Positron Emission Tomography Computed Tomography - administration & dosage
- Glucocorticoids - therapeutic use
- Biomarkers - administration & dosage
- Interleukin-6 - administration & dosage
- Find related publications in this database (Keywords)
- Giant Cell Arteritis
- Vasculitis
- Ultrasonography
- Cytokines
- Outcome and Process Assessment, Health Care