Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Guan, X; Lancione, M; Ayton, S; Dusek, P; Langkammer, C; Zhang, M.
Neuroimaging of Parkinson's disease by quantitative susceptibility mapping.
Neuroimage. 2024; 289:120547
Doi: 10.1016/j.neuroimage.2024.120547
Web of Science
PubMed
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FullText_MUG
- Führende Autor*innen der Med Uni Graz
- Langkammer Christian
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- Abstract:
- Parkinson's disease (PD) is a common neurodegenerative disease, and apart from a few rare genetic causes, its pathogenesis remains largely unclear. Recent scientific interest has been captured by the involvement of iron biochemistry and the disruption of iron homeostasis, particularly within the brain regions specifically affected in PD. The advent of Quantitative Susceptibility Mapping (QSM) has enabled non-invasive quantification of brain iron in vivo by MRI, which has contributed to the understanding of iron-associated pathogenesis and has the potential for the development of iron-based biomarkers in PD. This review elucidates the biochemical underpinnings of brain iron accumulation, details advancements in iron-sensitive MRI technologies, and discusses the role of QSM as a biomarker of iron deposition in PD. Despite considerable progress, several challenges impede its clinical application after a decade of QSM studies. The initiation of multi-site research is warranted for developing robust, interpretable, and disease-specific biomarkers for monitoring PD disease progression.
- Find related publications in this database (using NLM MeSH Indexing)
- Humans - administration & dosage
- Parkinson Disease - diagnostic imaging, pathology
- Neurodegenerative Diseases - administration & dosage
- Neuroimaging - administration & dosage
- Magnetic Resonance Imaging - methods
- Biomarkers - administration & dosage
- Iron - administration & dosage
- Disease Progression - administration & dosage
- Brain Mapping - methods
- Find related publications in this database (Keywords)
- Quantitative susceptibility mapping
- Magnetic resonance imaging
- Parkinson 's disease
- Iron