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Arefnia, B; Horina, A; Nazerani-Zemann, T; Seinost, G; Rieder, M; Wimmer, G.
Nuclear imaging to visualize periodontal inflammation: Findings of a randomized controlled trial.
Oral Dis. 2024; 30(7):4630-4638 Doi: 10.1111/odi.14916
Web of Science PubMed FullText FullText_MUG

Leading authors Med Uni Graz: Arefnia Behrouz
Co-authors Med Uni Graz: Horina Anja; Nazerani-Zemann Tina; Rieder Marcus; Seinost Gerald; Wimmer Gernot
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Abstract:: OBJECTIVE: To investigate non-surgical periodontal therapy by 18F-fluorodeoxyglucose (2-[¹⁸F]FDG) uptake using positron emission tomography (PET) integrated with computed tomography (CT). SUBJECTS: Eighty-five patients with peripheral artery disease and severe periodontitis-randomized into three groups receiving therapy with (PT1; n = 29) or without (PT2; n = 28) systemic antibiotics or no treatment (controls: n = 28)-underwent nuclear imaging at baseline and at 3 months. RESULTS: Clinical inflammation (periodontal inflamed surface area; PISA) did not significantly differ across the groups at baseline (p = 0.395) but was significantly reduced at 3 months (p < 0.001), and significantly more so in the PT1/PT2 groups than in the control group (p < 0.001/=0.025) and in the PT1 than in the P2 group (p = 0.001). Radiotracer uptake was measured in both jaws using maximum and mean 'standardized uptake values' (SUV_max, SUV_mean) and 'target-to-background ratios' (TBR_max, TBR_mean). At 3 months, reductions were relatively small in absolute numbers and fell short of revealing correlations with PISA or significant differences across the groups. Still, they were very consistent in both treatment groups, whereas reductions were not consistently seen in the control group. CONCLUSIONS: 2-[¹⁸F]FDG PET/CT scans did reflect the clinical effects of periodontal treatment very consistently but, for reasons yet to be clarified, less closely than expected.
Find related publications in this database (using NLM MeSH Indexing): Humans - administration & dosage; Female - administration & dosage; Male - administration & dosage; Fluorodeoxyglucose F18 - administration & dosage; Radiopharmaceuticals - administration & dosage; Middle Aged - administration & dosage; Aged - administration & dosage; Periodontitis - diagnostic imaging, therapy; Anti-Bacterial Agents - therapeutic use; Positron Emission Tomography Computed Tomography - methods; Positron-Emission Tomography - administration & dosage
Find related publications in this database (Keywords): computed tomography; diagnostic imaging; periodontal treatment; periodontitis; positron emission tomography; radionuclide imaging