Medizinische Universität Graz - Research portal
Selected Publication:
SHR Neuro Cancer Cardio Lipid Metab Microb
Talakić, E; Kaufmann-Bühler, AK; Igrec, J; Adelsmayr, G; Janisch, M; Döller, C; Geyer, E; Lackner, K; Fuchsjäger, M; Schöllnast, H.
Perfusion Computed Tomography in Rectal Carcinoma: Influence of Optimization of the Patlak Range on Calculation of Equivalent Blood Volume and Flow Extraction.
J COMPUT ASSIST TOMO. 2023; 47(6): 850-855.
Doi: 10.1097/RCT.0000000000001506
Web of Science
PubMed
FullText
FullText_MUG
- Leading authors Med Uni Graz
- Fuchsjäger Michael
- Talakic Emina
- Co-authors Med Uni Graz
- Adelsmayr Gabriel
- Döller Carmen
- Igrec Jasminka
- Janisch Michael August Johann
- Kaufmann-Bühler Ann-Katrin
- Lackner Karoline
- Schoellnast Helmut
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- Abstract:
- PURPOSE: The aim of the study is to assess the influence of manual adjustment of the Patlak range in computed tomography (CT) perfusion analysis of rectal carcinoma compared with default range of the perfusion software. METHODS: This study was approved by the institutional review board and informed consent was obtained. Twenty-one patients (12 male, 9 female; mean age ± SD, 59 ± 11 years) with rectal cancer were included and underwent perfusion CT before preoperative chemoradiotherapy. Equivalent blood volume (BV) and flow-extraction (FE) were calculated using the Patlak plot model. Two perfusion sets were calculated per patient, a perfusion set using the default setting as provided by the software (dBV, dFE) and an optimized perfusion set after manual adaption of the Patlak range (aBV, aFE), which was limited to the intravascular space clearance of contrast to the extravascular space. Perfusion values calculated with both methods were compared for significance in differences using the Wilcoxon test. A P value of 0.05 or less was defined as statistically significant. RESULTS: Adjustment of the Patlak range statistically significantly influenced BV and FE calculation. Median dBV was 23.2 mL/100 mL (interquartile range [IQR], 12.1 mL/100 mL), whereas median aBV was 20.3 mL/100 mL (IQR, 10.9 mL/100 mL). The difference in BV was statistically significant ( P = 0.021). Median dFE was 8.3 mL/min/100 mL (IQR, 4.7 mL/min/100 mL), whereas median aFE was 15.4 mL/min/100 mL (IQR, 5.8 mL/min/100 mL). The difference in FE was statistically significant ( P < 0.001). CONCLUSIONS: Our findings indicate that in perfusion CT of rectal carcinoma, adjustment of the Patlak range may significantly influence BV and FE compared with default setting of the software. This may contribute to standardization in the use of this technique for functional imaging of rectal cancer.
- Find related publications in this database (using NLM MeSH Indexing)
- Humans - administration & dosage
- Male - administration & dosage
- Female - administration & dosage
- Tomography, X-Ray Computed - methods
- Rectal Neoplasms - diagnostic imaging, therapy
- Blood Volume - administration & dosage
- Perfusion - administration & dosage
- Carcinoma - administration & dosage
- Find related publications in this database (Keywords)
- rectal cancer
- multidetector computed tomography
- perfusion imaging