Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
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SHR Neuro Krebs Kardio Lipid Stoffw Microb
Klim, SM; Prattes, J; Amerstorfer, F; Niedrist, T; Zurl, C; Stradner, M; Dreo, B; Glehr, G; Leithner, A; Glehr, M; Reinbacher, P; Sadoghi, P; Hauer, G.
Soluble Urokinase Plasminogen Activator Receptor (SuPAR) Analysis for Diagnosis of Periprosthetic Joint Infection.
Antibiotics (Basel). 2024; 13(2):
Doi: 10.3390/antibiotics13020179
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- Führende Autor*innen der Med Uni Graz
- Klim Sebastian Martin
- Niedrist Tobias Josef
- Co-Autor*innen der Med Uni Graz
- Amerstorfer Florian Ludwig
- Dreo Barbara
- Glehr Mathias
- Hauer Georg
- Leithner Andreas
- Prattes Jürgen
- Reinbacher Patrick
- Sadoghi Patrick
- Stradner Martin Helmut
- Zurl Christoph Johann
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- Abstract:
- Soluble urokinase plasminogen activator receptors (suPARs) are a biomarker for inflammatory diseases. This study aims to investigate its diagnostic properties regarding periprosthetic joint infections (PJI). This retrospective cohort study included adult patients who underwent joint puncture for suspected PJI. The presence of PJI was determined according to the criteria of the European Bone and Joint Infection Society (EBJIS). Laboratory study analyses included the determination of white blood cells (WBC) in whole blood, C-reactive protein (CRP) in blood plasma, and suPAR in both blood plasma and synovial fluid. Appropriate diagnostic cut-off values were identified utilizing Youden's J, and their diagnostic performance was determined by calculating the positive (PPV) and negative predictive value (NPV) for each marker. Sixty-seven cases were included in the final analysis. Forty-three samples (64%) were identified as periprosthetic joint infection (PJI) and twenty-four specimen (36%) were PJI negative cases. The PPV and NPV were 0.80 and 0.70 for synovial suPAR, 0.86 and 0.55 for CRP, 0.84 and 0.31 for WBC and 1.00 and 0.31 for plasma suPAR. Synovial suPAR showed a solid diagnostic performance in this study and has the potential to be an alternative or complementary biomarker for PJI. Further investigations in larger patient collectives are indicated.
- Find related publications in this database (Keywords)
- suPAR
- joint infection
- synovia
- inflammation
- diagnostic biomarker